Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma

Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm associated with the Kasabach–Merritt phenomenon (KMP), which is a consumptive coagulopathy with associated potentially life-threatening thrombocytopenia. There are no standardized treatment protocols for the management of KHE with KMP...

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Autores principales: Wang, Liang, Li, Jing, Wu, Changhua, Song, Dan, Liu, Zhuang, Niu, Yanli, Zhou, Jie, Guo, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391052/
https://www.ncbi.nlm.nih.gov/pubmed/35990005
http://dx.doi.org/10.3389/fped.2022.949950
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author Wang, Liang
Li, Jing
Wu, Changhua
Song, Dan
Liu, Zhuang
Niu, Yanli
Zhou, Jie
Guo, Lei
author_facet Wang, Liang
Li, Jing
Wu, Changhua
Song, Dan
Liu, Zhuang
Niu, Yanli
Zhou, Jie
Guo, Lei
author_sort Wang, Liang
collection PubMed
description Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm associated with the Kasabach–Merritt phenomenon (KMP), which is a consumptive coagulopathy with associated potentially life-threatening thrombocytopenia. There are no standardized treatment protocols for the management of KHE with KMP. Moreover, there are limited reports regarding the treatment of cases of rebound. Herein, we describe a rare case of rebound of KHE/KMP, during systemic sirolimus treatment, successfully treated with embolization and vincristine infusion combined with microwave ablation.
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spelling pubmed-93910522022-08-20 Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma Wang, Liang Li, Jing Wu, Changhua Song, Dan Liu, Zhuang Niu, Yanli Zhou, Jie Guo, Lei Front Pediatr Pediatrics Kaposiform hemangioendothelioma (KHE) is a rare vascular neoplasm associated with the Kasabach–Merritt phenomenon (KMP), which is a consumptive coagulopathy with associated potentially life-threatening thrombocytopenia. There are no standardized treatment protocols for the management of KHE with KMP. Moreover, there are limited reports regarding the treatment of cases of rebound. Herein, we describe a rare case of rebound of KHE/KMP, during systemic sirolimus treatment, successfully treated with embolization and vincristine infusion combined with microwave ablation. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9391052/ /pubmed/35990005 http://dx.doi.org/10.3389/fped.2022.949950 Text en Copyright © 2022 Wang, Li, Wu, Song, Liu, Niu, Zhou and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wang, Liang
Li, Jing
Wu, Changhua
Song, Dan
Liu, Zhuang
Niu, Yanli
Zhou, Jie
Guo, Lei
Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title_full Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title_fullStr Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title_full_unstemmed Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title_short Case report: Experience of a rare case of rebound of the Kasabach-Merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
title_sort case report: experience of a rare case of rebound of the kasabach-merritt phenomenon during sirolimus treatment in kaposiform hemangioendothelioma
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391052/
https://www.ncbi.nlm.nih.gov/pubmed/35990005
http://dx.doi.org/10.3389/fped.2022.949950
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