Polo-like kinase-1, Aurora kinase A and WEE1 kinase are promising druggable targets in CML cells displaying BCR::ABL1-independent resistance to tyrosine kinase inhibitors

In chronic myeloid leukemia (CML), Aurora kinase A and Polo like kinase 1 (PLK1), two serine-threonine kinases involved in the maintenance of genomic stability by preserving a functional G2/M checkpoint, have been implicated in BCR::ABL1-independent resistance to the tyrosine kinase inhibitor (TKI)...

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Detalles Bibliográficos
Autores principales: Mancini, Manuela, De Santis, Sara, Monaldi, Cecilia, Castagnetti, Fausto, Lonetti, Annalisa, Bruno, Samantha, Dan, Elisa, Sinigaglia, Barbara, Rosti, Gianantonio, Cavo, Michele, Gugliotta, Gabriele, Soverini, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391055/
https://www.ncbi.nlm.nih.gov/pubmed/35992847
http://dx.doi.org/10.3389/fonc.2022.901132

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