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Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing

Diabetes is a systemic disease in which patients with diabetes may develop peripheral neuropathy of the lower extremities and peripheral vascular disease due to long-term continuous exposure to high glucose. Delayed wound healing in diabetes is one of the major complications of diabetes. Slow wound...

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Autores principales: Liu, Ye, Liu, Yiqiu, He, Wenjie, Mu, Xingrui, Wu, Xingqian, Deng, Junyu, Nie, Xuqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391070/
https://www.ncbi.nlm.nih.gov/pubmed/35990622
http://dx.doi.org/10.3389/fimmu.2022.918223
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author Liu, Ye
Liu, Yiqiu
He, Wenjie
Mu, Xingrui
Wu, Xingqian
Deng, Junyu
Nie, Xuqiang
author_facet Liu, Ye
Liu, Yiqiu
He, Wenjie
Mu, Xingrui
Wu, Xingqian
Deng, Junyu
Nie, Xuqiang
author_sort Liu, Ye
collection PubMed
description Diabetes is a systemic disease in which patients with diabetes may develop peripheral neuropathy of the lower extremities and peripheral vascular disease due to long-term continuous exposure to high glucose. Delayed wound healing in diabetes is one of the major complications of diabetes. Slow wound healing in diabetic patients is associated with high glucose toxicity. When the condition deteriorates, the patient needs to be amputated, which seriously affects the quality of life and even endangers the life of the patient. In general, the delayed healing of diabetes wound is due to the lack of chemokines, abnormal inflammatory response, lack of angiogenesis and epithelial formation, and fibroblast dysfunction. The incidence of several chronic debilitating conditions is increasing in patients with diabetes, such as chronic renal insufficiency, heart failure, and hepatic insufficiency. Fibrosis is an inappropriate deposition of extracellular matrix (ECM) proteins. It is common in diabetic patients causing organ dysfunction. The fibrotic mechanism of diabetic fibroblasts may involve direct activation of permanent fibroblasts. It may also involve the degeneration of fibers after hyperglycemia stimulates immune cells, vascular cells, or organ-specific parenchymal cells. Numerous studies confirm that fibroblasts play an essential role in treating diabetes and its complications. The primary function of fibroblasts in wound healing is to construct and reshape the ECM. Nowadays, with the widespread use of single-cell RNA sequencing (scRNA-seq), an increasing number of studies have found that fibroblasts have become the critical immune sentinel cells, which can detect not only the activation and regulation of immune response but also the molecular pattern related to the injury. By exploring the heterogeneity and functional changes of fibroblasts in diabetes, the manuscript discusses that fibroblasts may be used as immunomodulatory factors in refractory diabetic wound healing, providing new ideas for the treatment of refractory diabetic wound healing.
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spelling pubmed-93910702022-08-20 Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing Liu, Ye Liu, Yiqiu He, Wenjie Mu, Xingrui Wu, Xingqian Deng, Junyu Nie, Xuqiang Front Immunol Immunology Diabetes is a systemic disease in which patients with diabetes may develop peripheral neuropathy of the lower extremities and peripheral vascular disease due to long-term continuous exposure to high glucose. Delayed wound healing in diabetes is one of the major complications of diabetes. Slow wound healing in diabetic patients is associated with high glucose toxicity. When the condition deteriorates, the patient needs to be amputated, which seriously affects the quality of life and even endangers the life of the patient. In general, the delayed healing of diabetes wound is due to the lack of chemokines, abnormal inflammatory response, lack of angiogenesis and epithelial formation, and fibroblast dysfunction. The incidence of several chronic debilitating conditions is increasing in patients with diabetes, such as chronic renal insufficiency, heart failure, and hepatic insufficiency. Fibrosis is an inappropriate deposition of extracellular matrix (ECM) proteins. It is common in diabetic patients causing organ dysfunction. The fibrotic mechanism of diabetic fibroblasts may involve direct activation of permanent fibroblasts. It may also involve the degeneration of fibers after hyperglycemia stimulates immune cells, vascular cells, or organ-specific parenchymal cells. Numerous studies confirm that fibroblasts play an essential role in treating diabetes and its complications. The primary function of fibroblasts in wound healing is to construct and reshape the ECM. Nowadays, with the widespread use of single-cell RNA sequencing (scRNA-seq), an increasing number of studies have found that fibroblasts have become the critical immune sentinel cells, which can detect not only the activation and regulation of immune response but also the molecular pattern related to the injury. By exploring the heterogeneity and functional changes of fibroblasts in diabetes, the manuscript discusses that fibroblasts may be used as immunomodulatory factors in refractory diabetic wound healing, providing new ideas for the treatment of refractory diabetic wound healing. Frontiers Media S.A. 2022-08-05 /pmc/articles/PMC9391070/ /pubmed/35990622 http://dx.doi.org/10.3389/fimmu.2022.918223 Text en Copyright © 2022 Liu, Liu, He, Mu, Wu, Deng and Nie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Ye
Liu, Yiqiu
He, Wenjie
Mu, Xingrui
Wu, Xingqian
Deng, Junyu
Nie, Xuqiang
Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title_full Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title_fullStr Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title_full_unstemmed Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title_short Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing
title_sort fibroblasts: immunomodulatory factors in refractory diabetic wound healing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391070/
https://www.ncbi.nlm.nih.gov/pubmed/35990622
http://dx.doi.org/10.3389/fimmu.2022.918223
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