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Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice

The present study aimed to evaluate the antiobesity potential and synergistic effects of ALM16, a mixture of Astragalus membranaceus (AM) and Lithospermum erythrorhizon (LE) extracts, in HFD-induced obese mice. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD + AM, HFD + LE or HFD ...

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Autores principales: Choi, Doo Jin, Choi, Bo-Ram, Lee, HaeJin, Kim, Seong Cheol, Yoon, Dahye, Lee, Young-Seob, Han, Kyung-Sook, Park, Sung-Bum, Kim, Geum-Soog, Lee, Dae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391103/
https://www.ncbi.nlm.nih.gov/pubmed/35990844
http://dx.doi.org/10.1155/2022/9642427
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author Choi, Doo Jin
Choi, Bo-Ram
Lee, HaeJin
Kim, Seong Cheol
Yoon, Dahye
Lee, Young-Seob
Han, Kyung-Sook
Park, Sung-Bum
Kim, Geum-Soog
Lee, Dae Young
author_facet Choi, Doo Jin
Choi, Bo-Ram
Lee, HaeJin
Kim, Seong Cheol
Yoon, Dahye
Lee, Young-Seob
Han, Kyung-Sook
Park, Sung-Bum
Kim, Geum-Soog
Lee, Dae Young
author_sort Choi, Doo Jin
collection PubMed
description The present study aimed to evaluate the antiobesity potential and synergistic effects of ALM16, a mixture of Astragalus membranaceus (AM) and Lithospermum erythrorhizon (LE) extracts, in HFD-induced obese mice. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD + AM, HFD + LE or HFD + ALM16 (50, 100, and 200 mg/kg) daily for 5 weeks. Compared to the ND group, HFD-fed mice showed significant increases in body weight, food efficiency ratio, weights of white adipose tissues, adipocytes size, liver weight, and hepatic steatosis grade. However, ALM16 significantly reduced those increases induced by HFD. Moreover, as compared to the HFD group, the ALM16 group significantly ameliorated serum levels of lipid profiles (TG, TC, HDL, and LDL), adipokines (leptin and adiponectin), and liver damage markers (AST and ALT levels). Notably, ALM16 was more effective than AM or LE alone and had a similar or more potent effect than Garcinia cambogia extracts, as a positive control, at the same dose. These results demonstrate that ALM16 synergistically exerts anti-obesity effects based on complementary interactions between each component. Also, metabolic profiling between each extract and the ALM16 was confirmed by UPLC-QTOF/MS, and the difference was confirmed by relative quantification.
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spelling pubmed-93911032022-08-20 Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice Choi, Doo Jin Choi, Bo-Ram Lee, HaeJin Kim, Seong Cheol Yoon, Dahye Lee, Young-Seob Han, Kyung-Sook Park, Sung-Bum Kim, Geum-Soog Lee, Dae Young Evid Based Complement Alternat Med Research Article The present study aimed to evaluate the antiobesity potential and synergistic effects of ALM16, a mixture of Astragalus membranaceus (AM) and Lithospermum erythrorhizon (LE) extracts, in HFD-induced obese mice. C57BL/6 mice were fed a normal diet (ND), high-fat diet (HFD), HFD + AM, HFD + LE or HFD + ALM16 (50, 100, and 200 mg/kg) daily for 5 weeks. Compared to the ND group, HFD-fed mice showed significant increases in body weight, food efficiency ratio, weights of white adipose tissues, adipocytes size, liver weight, and hepatic steatosis grade. However, ALM16 significantly reduced those increases induced by HFD. Moreover, as compared to the HFD group, the ALM16 group significantly ameliorated serum levels of lipid profiles (TG, TC, HDL, and LDL), adipokines (leptin and adiponectin), and liver damage markers (AST and ALT levels). Notably, ALM16 was more effective than AM or LE alone and had a similar or more potent effect than Garcinia cambogia extracts, as a positive control, at the same dose. These results demonstrate that ALM16 synergistically exerts anti-obesity effects based on complementary interactions between each component. Also, metabolic profiling between each extract and the ALM16 was confirmed by UPLC-QTOF/MS, and the difference was confirmed by relative quantification. Hindawi 2022-08-12 /pmc/articles/PMC9391103/ /pubmed/35990844 http://dx.doi.org/10.1155/2022/9642427 Text en Copyright © 2022 Doo Jin Choi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Choi, Doo Jin
Choi, Bo-Ram
Lee, HaeJin
Kim, Seong Cheol
Yoon, Dahye
Lee, Young-Seob
Han, Kyung-Sook
Park, Sung-Bum
Kim, Geum-Soog
Lee, Dae Young
Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title_full Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title_fullStr Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title_full_unstemmed Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title_short Chemical Profiles and Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract in High Fat Diet Fed Mice
title_sort chemical profiles and antiobesity effect of a mixture of astragalus membranaceus and lithospermum erythrorhizon extract in high fat diet fed mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391103/
https://www.ncbi.nlm.nih.gov/pubmed/35990844
http://dx.doi.org/10.1155/2022/9642427
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