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The Mechanism of TNF-α-Mediated Accumulation of Phosphorylated Tau Protein and Its Modulation by Propofol in Primary Mouse Hippocampal Neurons: Role of Mitophagy, NLRP3, and p62/Keap1/Nrf2 Pathway

BACKGROUND: Neuroinflammation-induced phosphorylated Tau (p-Tau) deposition in central nervous system contributes to neurodegenerative disorders. Propofol possesses neuroprotective properties. We investigated its impacts on tumor necrosis factor-α (TNF-α)-mediated p-Tau deposition in neurons. METHOD...

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Detalles Bibliográficos
Autores principales:	Zhang, Lin, Song, Hong, Ding, Jie, Wang, Dong-jie, Zhu, Shi-peng, Liu, Chi, Jin, Xian, Chen, Jia-wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391138/ https://www.ncbi.nlm.nih.gov/pubmed/35993019 http://dx.doi.org/10.1155/2022/8661200

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