Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis

An imbalance of human mesenchymal stem cells (hMSCs) adipogenic and osteogenic differentiation is crucial in the pathogenesis of osteoporosis, and elucidation of the underlying mechanism is urgently needed. APPL1, an adaptor protein of the adiponectin receptor, was recently shown to be closely relat...

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Detalles Bibliográficos
Autores principales: Zhang, Yunhui, Liu, Wenjie, Yuan, Weiquan, Cai, Zhaopeng, Ye, Guiwen, Zheng, Guan, Xu, Chenhao, Wang, Xinglang, zeng, Chenying, Mi, Rujia, Feng, Pei, Chen, Fenglei, Wu, Yanfeng, Shen, Huiyong, Wang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391247/
https://www.ncbi.nlm.nih.gov/pubmed/35984564
http://dx.doi.org/10.1007/s00018-022-04511-y

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