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Chemokine receptor CCR9 suppresses the differentiation of CD4(+)CD8αα(+) intraepithelial T cells in the gut

The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small intestine (SI). Notably, CCR9 is mostly expressed on CD8 but not on CD4 lineage T cells, thus imposing distinct tissue tropism on CD4 and CD8 T cells. The...

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Detalles Bibliográficos
Autores principales:	Li, Can, Kim, Hye Kyung, Prakhar, Praveen, Luo, Shunqun, Crossman, Assiatu, Ligons, Davinna L., Luckey, Megan A., Awasthi, Parirokh, Gress, Ronald E., Park, Jung-Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391308/ https://www.ncbi.nlm.nih.gov/pubmed/35778600 http://dx.doi.org/10.1038/s41385-022-00540-9

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