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Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6

The E1 enzyme Uba6 initiates signal transduction by activating ubiquitin and the ubiquitin-like protein FAT10 in a two-step process involving sequential catalysis of adenylation and thioester bond formation. To gain mechanistic insights into these processes, we determined the crystal structure of a...

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Detalles Bibliográficos
Autores principales:	Yuan, Lingmin, Gao, Fei, Lv, Zongyang, Nayak, Digant, Nayak, Anindita, Santos Bury, Priscila dos, Cano, Kristin E., Jia, Lijia, Oleinik, Natalia, Atilgan, Firdevs Cansu, Ogretmen, Besim, Williams, Katelyn M., Davies, Christopher, El Oualid, Farid, Wasmuth, Elizabeth V., Olsen, Shaun K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391358/ https://www.ncbi.nlm.nih.gov/pubmed/35986001 http://dx.doi.org/10.1038/s41467-022-32613-5

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