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A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea

To evaluate the real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) in Korea, focusing on retinal fluid resolution. This multi-institutional retrospective chart review study, analyzed medical records of patients with nAMD (age ≥ 50 years) who received t...

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Autores principales: Kim, Jae Hui, Sagong, Min, Woo, Se Joon, Kim, Yu Cheol, Cho, Heeyoon, Lee, Young Hoon, Byon, Iksoo, Jo, Young Joon, Chin, Hee Seung, Lee, Youkyung, Chae, Jae Eun, Kang, Se Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391430/
https://www.ncbi.nlm.nih.gov/pubmed/35986074
http://dx.doi.org/10.1038/s41598-022-18158-z
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author Kim, Jae Hui
Sagong, Min
Woo, Se Joon
Kim, Yu Cheol
Cho, Heeyoon
Lee, Young Hoon
Byon, Iksoo
Jo, Young Joon
Chin, Hee Seung
Lee, Youkyung
Chae, Jae Eun
Kang, Se Woong
author_facet Kim, Jae Hui
Sagong, Min
Woo, Se Joon
Kim, Yu Cheol
Cho, Heeyoon
Lee, Young Hoon
Byon, Iksoo
Jo, Young Joon
Chin, Hee Seung
Lee, Youkyung
Chae, Jae Eun
Kang, Se Woong
author_sort Kim, Jae Hui
collection PubMed
description To evaluate the real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) in Korea, focusing on retinal fluid resolution. This multi-institutional retrospective chart review study, analyzed medical records of patients with nAMD (age ≥ 50 years) who received their first anti-vascular endothelial growth factor (VEGF) treatment in ophthalmology clinics across South Korea between January 2017 and March 2019. The primary endpoint was the proportion of patients with retinal fluid after 12 months of anti-VEGF treatment. The association between fluid-free period and VA gains was also evaluated. A total of 600 patients were enrolled. At baseline, 97.16% of patients had retinal fluid; after 12 months of anti-VEGF treatment, 58.10% of patients had persistent retinal fluid. VA improvements were relatively better in patients with absence of retinal fluid compared with presence of retinal fluid (+ 12.29 letters vs. + 6.45 letters at month 12; P < .0001). Longer duration of absence of retinal fluid over first 12 months correlated with better VA gains at month 12 (P < .01). More than half of the study patients with nAMD had retinal fluid even after 12 months of treatment with their current anti-VEGF. Presence of retinal fluid was associated with relatively worse VA outcomes.
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spelling pubmed-93914302022-08-21 A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea Kim, Jae Hui Sagong, Min Woo, Se Joon Kim, Yu Cheol Cho, Heeyoon Lee, Young Hoon Byon, Iksoo Jo, Young Joon Chin, Hee Seung Lee, Youkyung Chae, Jae Eun Kang, Se Woong Sci Rep Article To evaluate the real-world treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) in Korea, focusing on retinal fluid resolution. This multi-institutional retrospective chart review study, analyzed medical records of patients with nAMD (age ≥ 50 years) who received their first anti-vascular endothelial growth factor (VEGF) treatment in ophthalmology clinics across South Korea between January 2017 and March 2019. The primary endpoint was the proportion of patients with retinal fluid after 12 months of anti-VEGF treatment. The association between fluid-free period and VA gains was also evaluated. A total of 600 patients were enrolled. At baseline, 97.16% of patients had retinal fluid; after 12 months of anti-VEGF treatment, 58.10% of patients had persistent retinal fluid. VA improvements were relatively better in patients with absence of retinal fluid compared with presence of retinal fluid (+ 12.29 letters vs. + 6.45 letters at month 12; P < .0001). Longer duration of absence of retinal fluid over first 12 months correlated with better VA gains at month 12 (P < .01). More than half of the study patients with nAMD had retinal fluid even after 12 months of treatment with their current anti-VEGF. Presence of retinal fluid was associated with relatively worse VA outcomes. Nature Publishing Group UK 2022-08-19 /pmc/articles/PMC9391430/ /pubmed/35986074 http://dx.doi.org/10.1038/s41598-022-18158-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Jae Hui
Sagong, Min
Woo, Se Joon
Kim, Yu Cheol
Cho, Heeyoon
Lee, Young Hoon
Byon, Iksoo
Jo, Young Joon
Chin, Hee Seung
Lee, Youkyung
Chae, Jae Eun
Kang, Se Woong
A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title_full A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title_fullStr A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title_full_unstemmed A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title_short A real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in Korea
title_sort real-world study assessing the impact of retinal fluid on visual acuity outcomes in patients with neovascular age-related macular degeneration in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391430/
https://www.ncbi.nlm.nih.gov/pubmed/35986074
http://dx.doi.org/10.1038/s41598-022-18158-z
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