Catalytic synthesis of new pyrazolo [3,4-b] pyridine via a cooperative vinylogous anomeric-based oxidation

In this study, a novel nano-magnetic metal–organic frameworks based on Fe(3)O(4) namely Fe(3)O(4)@MIL-101(Cr)-N(CH(2)PO(3))(2) was synthesized and fully characterized. The prepared sample was used as catalyst in the synthesis of pyrazolo [3,4-b] pyridines as convenient medicine by condensation react...

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Detalles Bibliográficos
Autores principales: Sepehrmansourie, Hassan, Zarei, Mahmoud, Zolfigol, Mohammad Ali, Babaee, Saeed, Azizian, Saeid, Rostamnia, Sadegh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391453/
https://www.ncbi.nlm.nih.gov/pubmed/35986040
http://dx.doi.org/10.1038/s41598-022-17879-5
Descripción
Sumario:In this study, a novel nano-magnetic metal–organic frameworks based on Fe(3)O(4) namely Fe(3)O(4)@MIL-101(Cr)-N(CH(2)PO(3))(2) was synthesized and fully characterized. The prepared sample was used as catalyst in the synthesis of pyrazolo [3,4-b] pyridines as convenient medicine by condensation reaction of aldehydes, 5-(1H-Indol-3-yl)- 2H-pyrazol-3-ylamine and 3-(cyanoacetyl)indole via a CVABO. The products were obtained with high yields at 100 °C and under solvent-free conditions.

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