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Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults. The oncogenic homo-tetrameric fusion protein RUNX1/ETO results from the chromosomal translocation t(8;21) and is found in AML patients. The nervy homology region 2 (NHR2)...

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Detalles Bibliográficos
Autores principales:	Gopalswamy, Mohanraj, Kroeger, Tobias, Bickel, David, Frieg, Benedikt, Akter, Shahina, Schott-Verdugo, Stephan, Viegas, Aldino, Pauly, Thomas, Mayer, Manuela, Przibilla, Julia, Reiners, Jens, Nagel-Steger, Luitgard, Smits, Sander H. J., Groth, Georg, Etzkorn, Manuel, Gohlke, Holger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391460/ https://www.ncbi.nlm.nih.gov/pubmed/35986043 http://dx.doi.org/10.1038/s41598-022-17913-6

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