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Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T

Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined...

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Autores principales: Rodriguez, Gonzalo G., Yu, Zidan, O′Donnell, Lauren F., Calderon, Liz, Cloos, Martijn A., Madelin, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391473/
https://www.ncbi.nlm.nih.gov/pubmed/35986071
http://dx.doi.org/10.1038/s41598-022-18388-1
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author Rodriguez, Gonzalo G.
Yu, Zidan
O′Donnell, Lauren F.
Calderon, Liz
Cloos, Martijn A.
Madelin, Guillaume
author_facet Rodriguez, Gonzalo G.
Yu, Zidan
O′Donnell, Lauren F.
Calderon, Liz
Cloos, Martijn A.
Madelin, Guillaume
author_sort Rodriguez, Gonzalo G.
collection PubMed
description Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined use in a single experiment. In this work, we assessed the repeatability of normalized proton density (PD), T(1), T(2), and normalized sodium density-weighted quantification measured with simultaneous 3D (1)H MRF/(23)Na MRI in the brain at 7 T, from ten healthy volunteers who were scanned three times each. The coefficients of variation (CV) and the intra-class correlation (ICC) were calculated for the mean and standard deviation (SD) of these 4 parameters in grey matter, white matter, and cerebrospinal fluid. As result, the CVs were lower than 3.3% for the mean values and lower than 6.9% for the SD values. The ICCs were higher than 0.61 in all 24 measurements. We conclude that the measurements of normalized PD, T(1), T(2), and normalized sodium density-weighted from simultaneous 3D (1)H MRF/(23)Na MRI in the brain at 7 T showed high repeatability. We estimate that changes > 6.6% (> 2 CVs) in mean values of both (1)H and (23)Na metrics could be detectable with this method.
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spelling pubmed-93914732022-08-21 Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T Rodriguez, Gonzalo G. Yu, Zidan O′Donnell, Lauren F. Calderon, Liz Cloos, Martijn A. Madelin, Guillaume Sci Rep Article Proton MRI can provide detailed morphological images, but it reveals little information about cell homeostasis. On the other hand, sodium MRI can provide metabolic information but cannot resolve fine structures. The complementary nature of proton and sodium MRI raises the prospect of their combined use in a single experiment. In this work, we assessed the repeatability of normalized proton density (PD), T(1), T(2), and normalized sodium density-weighted quantification measured with simultaneous 3D (1)H MRF/(23)Na MRI in the brain at 7 T, from ten healthy volunteers who were scanned three times each. The coefficients of variation (CV) and the intra-class correlation (ICC) were calculated for the mean and standard deviation (SD) of these 4 parameters in grey matter, white matter, and cerebrospinal fluid. As result, the CVs were lower than 3.3% for the mean values and lower than 6.9% for the SD values. The ICCs were higher than 0.61 in all 24 measurements. We conclude that the measurements of normalized PD, T(1), T(2), and normalized sodium density-weighted from simultaneous 3D (1)H MRF/(23)Na MRI in the brain at 7 T showed high repeatability. We estimate that changes > 6.6% (> 2 CVs) in mean values of both (1)H and (23)Na metrics could be detectable with this method. Nature Publishing Group UK 2022-08-19 /pmc/articles/PMC9391473/ /pubmed/35986071 http://dx.doi.org/10.1038/s41598-022-18388-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rodriguez, Gonzalo G.
Yu, Zidan
O′Donnell, Lauren F.
Calderon, Liz
Cloos, Martijn A.
Madelin, Guillaume
Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title_full Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title_fullStr Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title_full_unstemmed Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title_short Repeatability of simultaneous 3D (1)H MRF/(23)Na MRI in brain at 7 T
title_sort repeatability of simultaneous 3d (1)h mrf/(23)na mri in brain at 7 t
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391473/
https://www.ncbi.nlm.nih.gov/pubmed/35986071
http://dx.doi.org/10.1038/s41598-022-18388-1
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