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(D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism
(D)-Amino acids ((D)-AAs) have various functions in mammals and microbes. (D)-AAs are produced by gut microbiota and can act as potent bactericidal molecules. Thus, (D)-AAs regulate the ecological niche of the intestine; however, the actual impacts of (D)-AAs in the gut remain unknown. In this study...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391578/ https://www.ncbi.nlm.nih.gov/pubmed/35996581 http://dx.doi.org/10.1016/j.isci.2022.104838 |
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author | Seki, Natsumi Kimizuka, Tatsuki Gondo, Monica Yamaguchi, Genki Sugiura, Yuki Akiyama, Masahiro Yakabe, Kyosuke Uchiyama, Jun Higashi, Seiichiro Haneda, Takeshi Suematsu, Makoto Hase, Koji Kim, Yun-Gi |
author_facet | Seki, Natsumi Kimizuka, Tatsuki Gondo, Monica Yamaguchi, Genki Sugiura, Yuki Akiyama, Masahiro Yakabe, Kyosuke Uchiyama, Jun Higashi, Seiichiro Haneda, Takeshi Suematsu, Makoto Hase, Koji Kim, Yun-Gi |
author_sort | Seki, Natsumi |
collection | PubMed |
description | (D)-Amino acids ((D)-AAs) have various functions in mammals and microbes. (D)-AAs are produced by gut microbiota and can act as potent bactericidal molecules. Thus, (D)-AAs regulate the ecological niche of the intestine; however, the actual impacts of (D)-AAs in the gut remain unknown. In this study, we show that (D)-Tryptophan ((D)-Trp) inhibits the growth of enteric pathogen and colitogenic pathobionts. The growth of Citrobacter rodentium in vitro is strongly inhibited by (D)-Trp treatment. Moreover, (D)-Trp protects mice from lethal C. rodentium infection via reduction of the pathogen. Additionally, (D)-Trp prevents the development of experimental colitis by the depletion of specific microbes in the intestine. (D)-Trp increases the intracellular level of indole acrylic acid (IA), a key molecule that determines the susceptibility of enteric microbes to (D)-Trp. Treatment with IA improves the survival of mice infected with C. rodentium. Hence, (D)-Trp could act as a gut environmental modulator that regulates intestinal homeostasis. |
format | Online Article Text |
id | pubmed-9391578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-93915782022-08-21 (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism Seki, Natsumi Kimizuka, Tatsuki Gondo, Monica Yamaguchi, Genki Sugiura, Yuki Akiyama, Masahiro Yakabe, Kyosuke Uchiyama, Jun Higashi, Seiichiro Haneda, Takeshi Suematsu, Makoto Hase, Koji Kim, Yun-Gi iScience Article (D)-Amino acids ((D)-AAs) have various functions in mammals and microbes. (D)-AAs are produced by gut microbiota and can act as potent bactericidal molecules. Thus, (D)-AAs regulate the ecological niche of the intestine; however, the actual impacts of (D)-AAs in the gut remain unknown. In this study, we show that (D)-Tryptophan ((D)-Trp) inhibits the growth of enteric pathogen and colitogenic pathobionts. The growth of Citrobacter rodentium in vitro is strongly inhibited by (D)-Trp treatment. Moreover, (D)-Trp protects mice from lethal C. rodentium infection via reduction of the pathogen. Additionally, (D)-Trp prevents the development of experimental colitis by the depletion of specific microbes in the intestine. (D)-Trp increases the intracellular level of indole acrylic acid (IA), a key molecule that determines the susceptibility of enteric microbes to (D)-Trp. Treatment with IA improves the survival of mice infected with C. rodentium. Hence, (D)-Trp could act as a gut environmental modulator that regulates intestinal homeostasis. Elsevier 2022-08-03 /pmc/articles/PMC9391578/ /pubmed/35996581 http://dx.doi.org/10.1016/j.isci.2022.104838 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Seki, Natsumi Kimizuka, Tatsuki Gondo, Monica Yamaguchi, Genki Sugiura, Yuki Akiyama, Masahiro Yakabe, Kyosuke Uchiyama, Jun Higashi, Seiichiro Haneda, Takeshi Suematsu, Makoto Hase, Koji Kim, Yun-Gi (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title | (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title_full | (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title_fullStr | (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title_full_unstemmed | (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title_short | (D)-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
title_sort | (d)-tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391578/ https://www.ncbi.nlm.nih.gov/pubmed/35996581 http://dx.doi.org/10.1016/j.isci.2022.104838 |
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