Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development

The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 pept...

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Detalles Bibliográficos
Autores principales: Sánchez-Burgos, Gilma, Herrera-Nájera, Carla, Cedillo-Rivera, Roberto, Dumonteil, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392039/
https://www.ncbi.nlm.nih.gov/pubmed/31760037
http://dx.doi.org/10.1016/j.bjid.2019.10.009
Descripción
Sumario:The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. This finding suggests that the low antibody response against P5 epitope could be a risk factor for higher susceptibility to dengue virus infection with warning signs, and that P5 could be a potential antigen for vaccine development.

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