Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development

The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 pept...

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Autores principales: Sánchez-Burgos, Gilma, Herrera-Nájera, Carla, Cedillo-Rivera, Roberto, Dumonteil, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392039/
https://www.ncbi.nlm.nih.gov/pubmed/31760037
http://dx.doi.org/10.1016/j.bjid.2019.10.009
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author Sánchez-Burgos, Gilma
Herrera-Nájera, Carla
Cedillo-Rivera, Roberto
Dumonteil, Eric
author_facet Sánchez-Burgos, Gilma
Herrera-Nájera, Carla
Cedillo-Rivera, Roberto
Dumonteil, Eric
author_sort Sánchez-Burgos, Gilma
collection PubMed
description The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. This finding suggests that the low antibody response against P5 epitope could be a risk factor for higher susceptibility to dengue virus infection with warning signs, and that P5 could be a potential antigen for vaccine development.
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spelling pubmed-93920392022-08-23 Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development Sánchez-Burgos, Gilma Herrera-Nájera, Carla Cedillo-Rivera, Roberto Dumonteil, Eric Braz J Infect Dis Brief Communication The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. This finding suggests that the low antibody response against P5 epitope could be a risk factor for higher susceptibility to dengue virus infection with warning signs, and that P5 could be a potential antigen for vaccine development. Elsevier 2019-11-21 /pmc/articles/PMC9392039/ /pubmed/31760037 http://dx.doi.org/10.1016/j.bjid.2019.10.009 Text en © 2019 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Brief Communication
Sánchez-Burgos, Gilma
Herrera-Nájera, Carla
Cedillo-Rivera, Roberto
Dumonteil, Eric
Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title_full Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title_fullStr Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title_full_unstemmed Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title_short Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
title_sort epitope of dengue virus e protein detect human antibodies associated with mild disease: a potential peptide for vaccine development
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392039/
https://www.ncbi.nlm.nih.gov/pubmed/31760037
http://dx.doi.org/10.1016/j.bjid.2019.10.009
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