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Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute Z...

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Autores principales: Bandeira, Antonio Carlos, Gois, Luana Leandro, Campos, Gubio Soares, Sardi, Silvia, Yssel, Hans, Vieillard, Vincent, Autran, Brigitte, Grassi, Maria Fernanda Rios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392112/
https://www.ncbi.nlm.nih.gov/pubmed/32941805
http://dx.doi.org/10.1016/j.bjid.2020.08.005
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author Bandeira, Antonio Carlos
Gois, Luana Leandro
Campos, Gubio Soares
Sardi, Silvia
Yssel, Hans
Vieillard, Vincent
Autran, Brigitte
Grassi, Maria Fernanda Rios
author_facet Bandeira, Antonio Carlos
Gois, Luana Leandro
Campos, Gubio Soares
Sardi, Silvia
Yssel, Hans
Vieillard, Vincent
Autran, Brigitte
Grassi, Maria Fernanda Rios
author_sort Bandeira, Antonio Carlos
collection PubMed
description Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.
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spelling pubmed-93921122022-08-23 Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic Bandeira, Antonio Carlos Gois, Luana Leandro Campos, Gubio Soares Sardi, Silvia Yssel, Hans Vieillard, Vincent Autran, Brigitte Grassi, Maria Fernanda Rios Braz J Infect Dis Original Article Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests. Elsevier 2020-09-14 /pmc/articles/PMC9392112/ /pubmed/32941805 http://dx.doi.org/10.1016/j.bjid.2020.08.005 Text en © 2020 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Bandeira, Antonio Carlos
Gois, Luana Leandro
Campos, Gubio Soares
Sardi, Silvia
Yssel, Hans
Vieillard, Vincent
Autran, Brigitte
Grassi, Maria Fernanda Rios
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_full Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_fullStr Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_full_unstemmed Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_short Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_sort clinical and laboratory findings of acute zika virus infection in patients from salvador during the first brazilian epidemic
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392112/
https://www.ncbi.nlm.nih.gov/pubmed/32941805
http://dx.doi.org/10.1016/j.bjid.2020.08.005
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