Two cases of neural tube defects with dolutegravir use at conception in south Brazil

Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two c...

Descripción completa

Detalles Bibliográficos
Autores principales: Kreitchmann, Regis, Oliveira, Fernando Rocha de, Sprinz, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392187/
https://www.ncbi.nlm.nih.gov/pubmed/33852885
http://dx.doi.org/10.1016/j.bjid.2021.101572
Descripción
Sumario:Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.

Ejemplares similares