Two cases of neural tube defects with dolutegravir use at conception in south Brazil

Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two c...

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Detalles Bibliográficos
Autores principales: Kreitchmann, Regis, Oliveira, Fernando Rocha de, Sprinz, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392187/
https://www.ncbi.nlm.nih.gov/pubmed/33852885
http://dx.doi.org/10.1016/j.bjid.2021.101572
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author Kreitchmann, Regis
Oliveira, Fernando Rocha de
Sprinz, Eduardo
author_facet Kreitchmann, Regis
Oliveira, Fernando Rocha de
Sprinz, Eduardo
author_sort Kreitchmann, Regis
collection PubMed
description Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.
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spelling pubmed-93921872022-08-23 Two cases of neural tube defects with dolutegravir use at conception in south Brazil Kreitchmann, Regis Oliveira, Fernando Rocha de Sprinz, Eduardo Braz J Infect Dis Case Report Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil. Elsevier 2021-04-11 /pmc/articles/PMC9392187/ /pubmed/33852885 http://dx.doi.org/10.1016/j.bjid.2021.101572 Text en © 2021 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kreitchmann, Regis
Oliveira, Fernando Rocha de
Sprinz, Eduardo
Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title_full Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title_fullStr Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title_full_unstemmed Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title_short Two cases of neural tube defects with dolutegravir use at conception in south Brazil
title_sort two cases of neural tube defects with dolutegravir use at conception in south brazil
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392187/
https://www.ncbi.nlm.nih.gov/pubmed/33852885
http://dx.doi.org/10.1016/j.bjid.2021.101572
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