Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

BACKGROUND: SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in the SP140 locus have been linked to Crohn’s disease (CD), suggesting a role in inflammation. RESULTS: We report the development of the first small mole...

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Detalles Bibliográficos
Autores principales: Ghiboub, Mohammed, Koster, Jan, Craggs, Peter D., Li Yim, Andrew Y. F., Shillings, Anthony, Hutchinson, Sue, Bingham, Ryan P., Gatfield, Kelly, Hageman, Ishtu L., Yao, Gang, O’Keefe, Heather P., Coffin, Aaron, Patel, Amish, Sloan, Lisa A., Mitchell, Darren J., Hayhow, Thomas G., Lunven, Laurent, Watson, Robert J., Blunt, Christopher E., Harrison, Lee A., Bruton, Gordon, Kumar, Umesh, Hamer, Natalie, Spaull, John R., Zwijnenburg, Danny A., Welting, Olaf, Hakvoort, Theodorus B. M., te Velde, Anje A., van Limbergen, Johan, Henneman, Peter, Prinjha, Rab K., de Winther, Menno P. J., Harker, Nicola R., Tough, David F., de Jonge, Wouter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392322/
https://www.ncbi.nlm.nih.gov/pubmed/35986286
http://dx.doi.org/10.1186/s12915-022-01380-6

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