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A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound

It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inh...

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Autores principales: Amjad, Elham, Sokouti, Babak, Asnaashari, Solmaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392350/
https://www.ncbi.nlm.nih.gov/pubmed/35986346
http://dx.doi.org/10.1186/s12935-022-02673-0
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author Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
author_facet Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
author_sort Amjad, Elham
collection PubMed
description It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is a multifaceted illness coordinated by multiple external and internal mechanisms. Natural extracts with the fewest side effects have piqued the attention of researchers in recent years, attempting to create cancer medicines based on them. An extensive array of natural product-derived anti-cancer agents have been examined to find a successful method. Numerous fruits and vegetables have high levels of naturally occurring flavonoid kaempferol, and its pharmacological and biological effects have been studied extensively. Certain forms of cancer are sensitive to kaempferol-mediated anti-cancer activity, although complete research is needed. We have endeavored to concentrate our review on controlling carcinogenic pathways by kaempferol in different malignancies. Aside from its extraordinary ability to modify cell processes, we have also discussed how kaempferol has the potential to be an effective therapy for numerous tumors.
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spelling pubmed-93923502022-08-21 A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound Amjad, Elham Sokouti, Babak Asnaashari, Solmaz Cancer Cell Int Review It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is a multifaceted illness coordinated by multiple external and internal mechanisms. Natural extracts with the fewest side effects have piqued the attention of researchers in recent years, attempting to create cancer medicines based on them. An extensive array of natural product-derived anti-cancer agents have been examined to find a successful method. Numerous fruits and vegetables have high levels of naturally occurring flavonoid kaempferol, and its pharmacological and biological effects have been studied extensively. Certain forms of cancer are sensitive to kaempferol-mediated anti-cancer activity, although complete research is needed. We have endeavored to concentrate our review on controlling carcinogenic pathways by kaempferol in different malignancies. Aside from its extraordinary ability to modify cell processes, we have also discussed how kaempferol has the potential to be an effective therapy for numerous tumors. BioMed Central 2022-08-20 /pmc/articles/PMC9392350/ /pubmed/35986346 http://dx.doi.org/10.1186/s12935-022-02673-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Amjad, Elham
Sokouti, Babak
Asnaashari, Solmaz
A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title_full A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title_fullStr A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title_full_unstemmed A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title_short A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
title_sort systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392350/
https://www.ncbi.nlm.nih.gov/pubmed/35986346
http://dx.doi.org/10.1186/s12935-022-02673-0
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