Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice

BACKGROUND: Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles transporting β-site amyloid precursor protein cleaving enz...

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Detalles Bibliográficos
Autores principales: Cuddy, Leah K., Alia, Alia O., Salvo, Miranda A., Chandra, Sidhanth, Grammatopoulos, Tom N., Justman, Craig J., Lansbury, Peter T., Mazzulli, Joseph R., Vassar, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392365/
https://www.ncbi.nlm.nih.gov/pubmed/35987691
http://dx.doi.org/10.1186/s13024-022-00561-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392365/
https://www.ncbi.nlm.nih.gov/pubmed/35987691
http://dx.doi.org/10.1186/s13024-022-00561-9

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