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Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes

BACKGROUND: In most cell types, replicative senescence (RS) is supposed to be a principle causative factor for aging. Atrial fibrosis, pathologically characterized by proliferation of atrial fibroblasts (AFs) and excessive accumulation of extracellular matrix proteins, is the most common substrate o...

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Detalles Bibliográficos
Autores principales:	Li, Yingze, Fang, Guojian, Cao, Wei, Yuan, Jiali, Song, Shuai, Peng, Hong, Wang, Yuepeng, Wang, Qunshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392478/ https://www.ncbi.nlm.nih.gov/pubmed/35996686 http://dx.doi.org/10.2147/JIR.S374951

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