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Recent Advances in Nano-Formulations for Skin Wound Repair Applications
Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392552/ https://www.ncbi.nlm.nih.gov/pubmed/35996567 http://dx.doi.org/10.2147/DDDT.S375541 |
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author | Lin, Yue Chen, Zheyan Liu, Yinai Wang, Jiawen Lv, Wang Peng, Renyi |
author_facet | Lin, Yue Chen, Zheyan Liu, Yinai Wang, Jiawen Lv, Wang Peng, Renyi |
author_sort | Lin, Yue |
collection | PubMed |
description | Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation or difficulty healing and other problems after treatment. Conventional treatment usually focuses on a single factor or process of wound repair and often ignores the influence of the wound pathological microenvironment on the final healing effect. Therefore, it is of substantial research value to develop multifunctional therapeutic methods that can actively regulate the wound microenvironment and reduce the oxidative stress level at the wound site to promote the repair of skin wounds. In recent years, various bioactive nanomaterials have shown great potential in tissue repair and regeneration due to their properties, including their unique surface interface effect, small size effect, enzyme activity and quantum effect. This review summarizes the mechanisms underlying skin wound repair and the defects in traditional treatment methods. We focus on analyzing the advantages of different types of nanomaterials and comment on their toxicity and side effects when used for skin wound repair. |
format | Online Article Text |
id | pubmed-9392552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-93925522022-08-21 Recent Advances in Nano-Formulations for Skin Wound Repair Applications Lin, Yue Chen, Zheyan Liu, Yinai Wang, Jiawen Lv, Wang Peng, Renyi Drug Des Devel Ther Review Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation or difficulty healing and other problems after treatment. Conventional treatment usually focuses on a single factor or process of wound repair and often ignores the influence of the wound pathological microenvironment on the final healing effect. Therefore, it is of substantial research value to develop multifunctional therapeutic methods that can actively regulate the wound microenvironment and reduce the oxidative stress level at the wound site to promote the repair of skin wounds. In recent years, various bioactive nanomaterials have shown great potential in tissue repair and regeneration due to their properties, including their unique surface interface effect, small size effect, enzyme activity and quantum effect. This review summarizes the mechanisms underlying skin wound repair and the defects in traditional treatment methods. We focus on analyzing the advantages of different types of nanomaterials and comment on their toxicity and side effects when used for skin wound repair. Dove 2022-08-16 /pmc/articles/PMC9392552/ /pubmed/35996567 http://dx.doi.org/10.2147/DDDT.S375541 Text en © 2022 Lin et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Lin, Yue Chen, Zheyan Liu, Yinai Wang, Jiawen Lv, Wang Peng, Renyi Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title | Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title_full | Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title_fullStr | Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title_full_unstemmed | Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title_short | Recent Advances in Nano-Formulations for Skin Wound Repair Applications |
title_sort | recent advances in nano-formulations for skin wound repair applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392552/ https://www.ncbi.nlm.nih.gov/pubmed/35996567 http://dx.doi.org/10.2147/DDDT.S375541 |
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