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Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization

METHODS: Based on the latest genome-wide association study summary data, bidirectional two-sample Mendelian randomization (MR) was employed to detect the causal relationship and effect direction between TSH, fT4, and CRP. Furthermore, in view of obesity being an important risk factor of CVD, obesity...

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Autores principales: Li, Tingting, Geng, Haigang, Wang, Yuquan, Wu, Zhaorong, Yang, Siqian, Hu, Yue-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392607/
https://www.ncbi.nlm.nih.gov/pubmed/35996695
http://dx.doi.org/10.1155/2022/8954606
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author Li, Tingting
Geng, Haigang
Wang, Yuquan
Wu, Zhaorong
Yang, Siqian
Hu, Yue-Qing
author_facet Li, Tingting
Geng, Haigang
Wang, Yuquan
Wu, Zhaorong
Yang, Siqian
Hu, Yue-Qing
author_sort Li, Tingting
collection PubMed
description METHODS: Based on the latest genome-wide association study summary data, bidirectional two-sample Mendelian randomization (MR) was employed to detect the causal relationship and effect direction between TSH, fT4, and CRP. Furthermore, in view of obesity being an important risk factor of CVD, obesity trait waist-hip ratio (WHR) and body mass index (BMI) were treated as the research objects in MR analyses for exploring the causal effects of TSH and fT4 on them, respectively. RESULTS: Genetically increased CRP was associated with increased TSH (β = −0.02, P = 0.011) and with increased fT4 (β = 0.043, P = 0.001), respectively, but there was no evidence that TSH or fT4 could affect CRP. In further analyses, genetically increased TSH was associated with decreased WHR (β = −0.02, P = 3.99e − 4). Genetically increased WHR was associated with decreased fT4 (β = −0.081, P = 0.002). Genetically increased BMI was associated with increased TSH (β = 0.03, P = 0.028) and with decreased fT4 (β = −0.078, P = 1.05e − 4). Causal associations of WHR and BMI with thyroid signaling were not supported by weighted median analysis in sensitivity analyses. CONCLUSION: TSH and fT4 were increased due to the higher genetically predicted CRP. WHR was decreased due to the higher genetically predicted TSH. These findings will provide reference for the prevention and treatment of inflammation and metabolic syndrome.
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spelling pubmed-93926072022-08-21 Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization Li, Tingting Geng, Haigang Wang, Yuquan Wu, Zhaorong Yang, Siqian Hu, Yue-Qing Comput Math Methods Med Research Article METHODS: Based on the latest genome-wide association study summary data, bidirectional two-sample Mendelian randomization (MR) was employed to detect the causal relationship and effect direction between TSH, fT4, and CRP. Furthermore, in view of obesity being an important risk factor of CVD, obesity trait waist-hip ratio (WHR) and body mass index (BMI) were treated as the research objects in MR analyses for exploring the causal effects of TSH and fT4 on them, respectively. RESULTS: Genetically increased CRP was associated with increased TSH (β = −0.02, P = 0.011) and with increased fT4 (β = 0.043, P = 0.001), respectively, but there was no evidence that TSH or fT4 could affect CRP. In further analyses, genetically increased TSH was associated with decreased WHR (β = −0.02, P = 3.99e − 4). Genetically increased WHR was associated with decreased fT4 (β = −0.081, P = 0.002). Genetically increased BMI was associated with increased TSH (β = 0.03, P = 0.028) and with decreased fT4 (β = −0.078, P = 1.05e − 4). Causal associations of WHR and BMI with thyroid signaling were not supported by weighted median analysis in sensitivity analyses. CONCLUSION: TSH and fT4 were increased due to the higher genetically predicted CRP. WHR was decreased due to the higher genetically predicted TSH. These findings will provide reference for the prevention and treatment of inflammation and metabolic syndrome. Hindawi 2022-08-13 /pmc/articles/PMC9392607/ /pubmed/35996695 http://dx.doi.org/10.1155/2022/8954606 Text en Copyright © 2022 Tingting Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Tingting
Geng, Haigang
Wang, Yuquan
Wu, Zhaorong
Yang, Siqian
Hu, Yue-Qing
Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title_full Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title_fullStr Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title_full_unstemmed Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title_short Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization
title_sort causal association of thyroid signaling with c-reactive protein: a bidirectional mendelian randomization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392607/
https://www.ncbi.nlm.nih.gov/pubmed/35996695
http://dx.doi.org/10.1155/2022/8954606
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