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Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants

Phenylalanine hydroxylase (PAH) is a key enzyme in mammals that maintains the phenylalanine (Phe) concentration at an appropriate physiological level. Some genetic mutations in the PAH gene lead to destabilization of the PAH enzyme, leading to phenylketonuria (PKU). Destabilized PAH variants can hav...

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Detalles Bibliográficos
Autores principales:	Sarodaya, Neha, Tyagi, Apoorvi, Kim, Hyun-Jin, Kang, Ju-Seop, Singh, Vijai, Hong, Seok-Ho, Kim, Woo Jin, Kim, Kye-Seong, Ramakrishna, Suresh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392723/ https://www.ncbi.nlm.nih.gov/pubmed/35987969 http://dx.doi.org/10.1038/s41598-022-18656-0

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