Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations

BACKGROUND: Since the start of COVID-19 vaccination worldwide, there have been several reports of inflammatory demyelinating diseases of the central nervous system (CNS-IDDs) following vaccination. METHODS: We prospectively collected cases of new-onset CNS-IDDs with a temporal relationship between d...

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Autores principales: Kim, Ki Hoon, Kim, Su-Hyun, Park, Na Young, Hyun, Jae-Won, Kim, Ho Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392895/
https://www.ncbi.nlm.nih.gov/pubmed/36037757
http://dx.doi.org/10.1016/j.msard.2022.104141
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author Kim, Ki Hoon
Kim, Su-Hyun
Park, Na Young
Hyun, Jae-Won
Kim, Ho Jin
author_facet Kim, Ki Hoon
Kim, Su-Hyun
Park, Na Young
Hyun, Jae-Won
Kim, Ho Jin
author_sort Kim, Ki Hoon
collection PubMed
description BACKGROUND: Since the start of COVID-19 vaccination worldwide, there have been several reports of inflammatory demyelinating diseases of the central nervous system (CNS-IDDs) following vaccination. METHODS: We prospectively collected cases of new-onset CNS-IDDs with a temporal relationship between disease onset and COVID-19 vaccination and investigated their proportion among newly registered cases of CNS-IDD over the past year. RESULTS: Among 117 cases, 10 (8.5%) had their first disease manifestation within one month following COVID-19 vaccination: 2 multiple sclerosis, 2 neuromyelitis optica spectrum disorder, 3 MOG antibody-associated disease, and 3 unclassified CNS-IDDs. CONCLUSION: This observation suggests that COVID-19 vaccination may trigger the onset of various CNS-IDDs in susceptible individuals.
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spelling pubmed-93928952022-08-22 Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations Kim, Ki Hoon Kim, Su-Hyun Park, Na Young Hyun, Jae-Won Kim, Ho Jin Mult Scler Relat Disord Article BACKGROUND: Since the start of COVID-19 vaccination worldwide, there have been several reports of inflammatory demyelinating diseases of the central nervous system (CNS-IDDs) following vaccination. METHODS: We prospectively collected cases of new-onset CNS-IDDs with a temporal relationship between disease onset and COVID-19 vaccination and investigated their proportion among newly registered cases of CNS-IDD over the past year. RESULTS: Among 117 cases, 10 (8.5%) had their first disease manifestation within one month following COVID-19 vaccination: 2 multiple sclerosis, 2 neuromyelitis optica spectrum disorder, 3 MOG antibody-associated disease, and 3 unclassified CNS-IDDs. CONCLUSION: This observation suggests that COVID-19 vaccination may trigger the onset of various CNS-IDDs in susceptible individuals. Elsevier B.V. 2022-12 2022-08-21 /pmc/articles/PMC9392895/ /pubmed/36037757 http://dx.doi.org/10.1016/j.msard.2022.104141 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kim, Ki Hoon
Kim, Su-Hyun
Park, Na Young
Hyun, Jae-Won
Kim, Ho Jin
Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title_full Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title_fullStr Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title_full_unstemmed Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title_short Onset of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
title_sort onset of various cns inflammatory demyelination diseases following covid-19 vaccinations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392895/
https://www.ncbi.nlm.nih.gov/pubmed/36037757
http://dx.doi.org/10.1016/j.msard.2022.104141
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