Towards establishing human body-on-a-chip systems

Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in th...

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Detalles Bibliográficos
Autores principales: Li, Zhong Alan, Tuan, Rocky S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392934/
https://www.ncbi.nlm.nih.gov/pubmed/35987699
http://dx.doi.org/10.1186/s13287-022-03130-5
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author Li, Zhong Alan
Tuan, Rocky S.
author_facet Li, Zhong Alan
Tuan, Rocky S.
author_sort Li, Zhong Alan
collection PubMed
description Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in their BoC system are discussed, followed by our future perspectives on enhancing the physiological relevance and scalability of BoCs for applications in studying disease mechanisms, testing potential therapeutics, and developing personalized medicine.
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spelling pubmed-93929342022-08-22 Towards establishing human body-on-a-chip systems Li, Zhong Alan Tuan, Rocky S. Stem Cell Res Ther Commentary Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in their BoC system are discussed, followed by our future perspectives on enhancing the physiological relevance and scalability of BoCs for applications in studying disease mechanisms, testing potential therapeutics, and developing personalized medicine. BioMed Central 2022-08-20 /pmc/articles/PMC9392934/ /pubmed/35987699 http://dx.doi.org/10.1186/s13287-022-03130-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Li, Zhong Alan
Tuan, Rocky S.
Towards establishing human body-on-a-chip systems
title Towards establishing human body-on-a-chip systems
title_full Towards establishing human body-on-a-chip systems
title_fullStr Towards establishing human body-on-a-chip systems
title_full_unstemmed Towards establishing human body-on-a-chip systems
title_short Towards establishing human body-on-a-chip systems
title_sort towards establishing human body-on-a-chip systems
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392934/
https://www.ncbi.nlm.nih.gov/pubmed/35987699
http://dx.doi.org/10.1186/s13287-022-03130-5
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