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A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic sign...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392974/ https://www.ncbi.nlm.nih.gov/pubmed/34784264 http://dx.doi.org/10.17305/bjbms.2021.6274 |
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author | Huang, Xianbo Zhou, De Ye, Xiujin Jin, Jie |
author_facet | Huang, Xianbo Zhou, De Ye, Xiujin Jin, Jie |
author_sort | Huang, Xianbo |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival (OS). The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation proved the signature efficient. The 12 FRGs signature was then used to assign patients into high- and low-risk groups, with the former exhibiting markedly reduced OS, compared to the low-risk group. ROC curve analysis verified the predictive ability of the risk model. Functional analysis showed that immune status and drug sensitivity differed between the two risk groups. In summary, FRGs is a promising candidate biomarker and therapeutic target for AML. |
format | Online Article Text |
id | pubmed-9392974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
record_format | MEDLINE/PubMed |
spelling | pubmed-93929742022-08-22 A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia Huang, Xianbo Zhou, De Ye, Xiujin Jin, Jie Bosn J Basic Med Sci Research Article Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival (OS). The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation proved the signature efficient. The 12 FRGs signature was then used to assign patients into high- and low-risk groups, with the former exhibiting markedly reduced OS, compared to the low-risk group. ROC curve analysis verified the predictive ability of the risk model. Functional analysis showed that immune status and drug sensitivity differed between the two risk groups. In summary, FRGs is a promising candidate biomarker and therapeutic target for AML. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022-08 2021-11-16 /pmc/articles/PMC9392974/ /pubmed/34784264 http://dx.doi.org/10.17305/bjbms.2021.6274 Text en Copyright: © The Author(s) (2022) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Research Article Huang, Xianbo Zhou, De Ye, Xiujin Jin, Jie A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title | A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title_full | A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title_fullStr | A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title_full_unstemmed | A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title_short | A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
title_sort | novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392974/ https://www.ncbi.nlm.nih.gov/pubmed/34784264 http://dx.doi.org/10.17305/bjbms.2021.6274 |
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