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A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia

Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic sign...

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Autores principales: Huang, Xianbo, Zhou, De, Ye, Xiujin, Jin, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392974/
https://www.ncbi.nlm.nih.gov/pubmed/34784264
http://dx.doi.org/10.17305/bjbms.2021.6274
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author Huang, Xianbo
Zhou, De
Ye, Xiujin
Jin, Jie
author_facet Huang, Xianbo
Zhou, De
Ye, Xiujin
Jin, Jie
author_sort Huang, Xianbo
collection PubMed
description Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival (OS). The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation proved the signature efficient. The 12 FRGs signature was then used to assign patients into high- and low-risk groups, with the former exhibiting markedly reduced OS, compared to the low-risk group. ROC curve analysis verified the predictive ability of the risk model. Functional analysis showed that immune status and drug sensitivity differed between the two risk groups. In summary, FRGs is a promising candidate biomarker and therapeutic target for AML.
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spelling pubmed-93929742022-08-22 A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia Huang, Xianbo Zhou, De Ye, Xiujin Jin, Jie Bosn J Basic Med Sci Research Article Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival (OS). The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation proved the signature efficient. The 12 FRGs signature was then used to assign patients into high- and low-risk groups, with the former exhibiting markedly reduced OS, compared to the low-risk group. ROC curve analysis verified the predictive ability of the risk model. Functional analysis showed that immune status and drug sensitivity differed between the two risk groups. In summary, FRGs is a promising candidate biomarker and therapeutic target for AML. Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2022-08 2021-11-16 /pmc/articles/PMC9392974/ /pubmed/34784264 http://dx.doi.org/10.17305/bjbms.2021.6274 Text en Copyright: © The Author(s) (2022) https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Research Article
Huang, Xianbo
Zhou, De
Ye, Xiujin
Jin, Jie
A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title_full A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title_fullStr A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title_full_unstemmed A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title_short A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
title_sort novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392974/
https://www.ncbi.nlm.nih.gov/pubmed/34784264
http://dx.doi.org/10.17305/bjbms.2021.6274
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