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Consensus guidelines on the construct validity of rodent models of restless legs syndrome
Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have prev...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393041/ https://www.ncbi.nlm.nih.gov/pubmed/35946581 http://dx.doi.org/10.1242/dmm.049615 |
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author | Salminen, Aaro V. Clemens, Stefan García-Borreguero, Diego Ghorayeb, Imad Li, Yuqing Manconi, Mauro Ondo, William Rye, David Siegel, Jerome M. Silvani, Alessandro Winkelman, John W. Allen, Richard P. Ferré, Sergi |
author_facet | Salminen, Aaro V. Clemens, Stefan García-Borreguero, Diego Ghorayeb, Imad Li, Yuqing Manconi, Mauro Ondo, William Rye, David Siegel, Jerome M. Silvani, Alessandro Winkelman, John W. Allen, Richard P. Ferré, Sergi |
author_sort | Salminen, Aaro V. |
collection | PubMed |
description | Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have previously defined face validity parameters for rodent models of RLS. In this article, we establish new guidelines for the construct validity of RLS rodent models. To do so, we first determined and agreed on the risk, and triggering factors and pathophysiological mechanisms that influence RLS expressivity. We then selected 20 items considered to have sufficient support in the literature, which we grouped by sex and genetic factors, iron-related mechanisms, electrophysiological mechanisms, dopaminergic mechanisms, exposure to medications active in the central nervous system, and others. These factors and biological mechanisms were then translated into rodent bioequivalents deemed to be most appropriate for a rodent model of RLS. We also identified parameters by which to assess and quantify these bioequivalents. Investigating these factors, both individually and in combination, will help to identify their specific roles in the expression of rodent RLS-like phenotypes, which should provide significant translational implications for the diagnosis and treatment of RLS. |
format | Online Article Text |
id | pubmed-9393041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-93930412022-08-22 Consensus guidelines on the construct validity of rodent models of restless legs syndrome Salminen, Aaro V. Clemens, Stefan García-Borreguero, Diego Ghorayeb, Imad Li, Yuqing Manconi, Mauro Ondo, William Rye, David Siegel, Jerome M. Silvani, Alessandro Winkelman, John W. Allen, Richard P. Ferré, Sergi Dis Model Mech Special Article Our understanding of the causes and natural course of restless legs syndrome (RLS) is incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical research and for the development of valid animal models. As a task force of preclinical and clinical scientists, we have previously defined face validity parameters for rodent models of RLS. In this article, we establish new guidelines for the construct validity of RLS rodent models. To do so, we first determined and agreed on the risk, and triggering factors and pathophysiological mechanisms that influence RLS expressivity. We then selected 20 items considered to have sufficient support in the literature, which we grouped by sex and genetic factors, iron-related mechanisms, electrophysiological mechanisms, dopaminergic mechanisms, exposure to medications active in the central nervous system, and others. These factors and biological mechanisms were then translated into rodent bioequivalents deemed to be most appropriate for a rodent model of RLS. We also identified parameters by which to assess and quantify these bioequivalents. Investigating these factors, both individually and in combination, will help to identify their specific roles in the expression of rodent RLS-like phenotypes, which should provide significant translational implications for the diagnosis and treatment of RLS. The Company of Biologists Ltd 2022-08-10 /pmc/articles/PMC9393041/ /pubmed/35946581 http://dx.doi.org/10.1242/dmm.049615 Text en © 2022. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Special Article Salminen, Aaro V. Clemens, Stefan García-Borreguero, Diego Ghorayeb, Imad Li, Yuqing Manconi, Mauro Ondo, William Rye, David Siegel, Jerome M. Silvani, Alessandro Winkelman, John W. Allen, Richard P. Ferré, Sergi Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title | Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title_full | Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title_fullStr | Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title_full_unstemmed | Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title_short | Consensus guidelines on the construct validity of rodent models of restless legs syndrome |
title_sort | consensus guidelines on the construct validity of rodent models of restless legs syndrome |
topic | Special Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393041/ https://www.ncbi.nlm.nih.gov/pubmed/35946581 http://dx.doi.org/10.1242/dmm.049615 |
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