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RNA binding proteins in osteoarthritis
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder. Its progression is characterized by aberrant expression of genes involved in inflammati...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393224/ https://www.ncbi.nlm.nih.gov/pubmed/36003144 http://dx.doi.org/10.3389/fcell.2022.954376 |
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author | Yi, Qian Deng, Zhenhan Yue, Jiaji He, Jinglong Xiong, Jianyi Sun, Wei Sun, Weichao |
author_facet | Yi, Qian Deng, Zhenhan Yue, Jiaji He, Jinglong Xiong, Jianyi Sun, Wei Sun, Weichao |
author_sort | Yi, Qian |
collection | PubMed |
description | Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder. Its progression is characterized by aberrant expression of genes involved in inflammation, proliferation, and metabolism of chondrocytes. Effective therapeutic strategies are limited, as mechanisms underlying OA pathophysiology remain unclear. Significant research efforts are ongoing to elucidate the complex molecular mechanisms underlying OA focused on gene transcription. However, posttranscriptional alterations also play significant function in inflammation and metabolic changes related diseases. RNA binding proteins (RBPs) have been recognized as important regulators in posttranscriptional regulation. RBPs regulate RNA subcellular localization, stability, and translational efficiency by binding to their target mRNAs, thereby controlling their protein expression. However, their role in OA is less clear. Identifying RBPs in OA is of great importance to better understand OA pathophysiology and to figure out potential targets for OA treatment. Hence, in this manuscript, we summarize the recent knowledge on the role of dysregulated RBPs in OA and hope it will provide new insight for OA study and targeted treatment. |
format | Online Article Text |
id | pubmed-9393224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93932242022-08-23 RNA binding proteins in osteoarthritis Yi, Qian Deng, Zhenhan Yue, Jiaji He, Jinglong Xiong, Jianyi Sun, Wei Sun, Weichao Front Cell Dev Biol Cell and Developmental Biology Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder. Its progression is characterized by aberrant expression of genes involved in inflammation, proliferation, and metabolism of chondrocytes. Effective therapeutic strategies are limited, as mechanisms underlying OA pathophysiology remain unclear. Significant research efforts are ongoing to elucidate the complex molecular mechanisms underlying OA focused on gene transcription. However, posttranscriptional alterations also play significant function in inflammation and metabolic changes related diseases. RNA binding proteins (RBPs) have been recognized as important regulators in posttranscriptional regulation. RBPs regulate RNA subcellular localization, stability, and translational efficiency by binding to their target mRNAs, thereby controlling their protein expression. However, their role in OA is less clear. Identifying RBPs in OA is of great importance to better understand OA pathophysiology and to figure out potential targets for OA treatment. Hence, in this manuscript, we summarize the recent knowledge on the role of dysregulated RBPs in OA and hope it will provide new insight for OA study and targeted treatment. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393224/ /pubmed/36003144 http://dx.doi.org/10.3389/fcell.2022.954376 Text en Copyright © 2022 Yi, Deng, Yue, He, Xiong, Sun and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Yi, Qian Deng, Zhenhan Yue, Jiaji He, Jinglong Xiong, Jianyi Sun, Wei Sun, Weichao RNA binding proteins in osteoarthritis |
title | RNA binding proteins in osteoarthritis |
title_full | RNA binding proteins in osteoarthritis |
title_fullStr | RNA binding proteins in osteoarthritis |
title_full_unstemmed | RNA binding proteins in osteoarthritis |
title_short | RNA binding proteins in osteoarthritis |
title_sort | rna binding proteins in osteoarthritis |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393224/ https://www.ncbi.nlm.nih.gov/pubmed/36003144 http://dx.doi.org/10.3389/fcell.2022.954376 |
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