Th2A cells: The pathogenic players in allergic diseases

Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3(+) CD4(+) HPGDS(+) CRTH2(+) CD161(high) ST2(high) CD49d(high) CD27(lo...

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Autores principales: Huang, Ziyu, Chu, Ming, Chen, Xi, Wang, Ziyuan, Jiang, Lin, Ma, Yinchao, Wang, Yuedan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393262/
https://www.ncbi.nlm.nih.gov/pubmed/36003397
http://dx.doi.org/10.3389/fimmu.2022.916778
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author Huang, Ziyu
Chu, Ming
Chen, Xi
Wang, Ziyuan
Jiang, Lin
Ma, Yinchao
Wang, Yuedan
author_facet Huang, Ziyu
Chu, Ming
Chen, Xi
Wang, Ziyuan
Jiang, Lin
Ma, Yinchao
Wang, Yuedan
author_sort Huang, Ziyu
collection PubMed
description Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3(+) CD4(+) HPGDS(+) CRTH2(+) CD161(high) ST2(high) CD49d(high) CD27(low) play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases.
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spelling pubmed-93932622022-08-23 Th2A cells: The pathogenic players in allergic diseases Huang, Ziyu Chu, Ming Chen, Xi Wang, Ziyuan Jiang, Lin Ma, Yinchao Wang, Yuedan Front Immunol Immunology Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3(+) CD4(+) HPGDS(+) CRTH2(+) CD161(high) ST2(high) CD49d(high) CD27(low) play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE). In this review, we summarize the discovery, biomarkers, and biological properties of Th2A cells to gain new insights into the pathogenesis of allergic diseases. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393262/ /pubmed/36003397 http://dx.doi.org/10.3389/fimmu.2022.916778 Text en Copyright © 2022 Huang, Chu, Chen, Wang, Jiang, Ma and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Huang, Ziyu
Chu, Ming
Chen, Xi
Wang, Ziyuan
Jiang, Lin
Ma, Yinchao
Wang, Yuedan
Th2A cells: The pathogenic players in allergic diseases
title Th2A cells: The pathogenic players in allergic diseases
title_full Th2A cells: The pathogenic players in allergic diseases
title_fullStr Th2A cells: The pathogenic players in allergic diseases
title_full_unstemmed Th2A cells: The pathogenic players in allergic diseases
title_short Th2A cells: The pathogenic players in allergic diseases
title_sort th2a cells: the pathogenic players in allergic diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393262/
https://www.ncbi.nlm.nih.gov/pubmed/36003397
http://dx.doi.org/10.3389/fimmu.2022.916778
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