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Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis

BACKGROUND: To evaluate the clinical outcomes and second-look arthroscopic findings after intra-articular adipose-derived regenerative cell (ADRC) injection as treatment for knee osteoarthritis (OA). METHODS: ADRCs were administered to 11 patients (19 knees; mean age, 61.7 years) with knee OA. Subcu...

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Autores principales: Onoi, Yuma, Hiranaka, Takafumi, Hida, Yuichi, Fujishiro, Takaaki, Okamoto, Koji, Matsumoto, Tomoyuki, Kuroda, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Orthopaedic Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393284/
https://www.ncbi.nlm.nih.gov/pubmed/36061847
http://dx.doi.org/10.4055/cios20312
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author Onoi, Yuma
Hiranaka, Takafumi
Hida, Yuichi
Fujishiro, Takaaki
Okamoto, Koji
Matsumoto, Tomoyuki
Kuroda, Ryosuke
author_facet Onoi, Yuma
Hiranaka, Takafumi
Hida, Yuichi
Fujishiro, Takaaki
Okamoto, Koji
Matsumoto, Tomoyuki
Kuroda, Ryosuke
author_sort Onoi, Yuma
collection PubMed
description BACKGROUND: To evaluate the clinical outcomes and second-look arthroscopic findings after intra-articular adipose-derived regenerative cell (ADRC) injection as treatment for knee osteoarthritis (OA). METHODS: ADRCs were administered to 11 patients (19 knees; mean age, 61.7 years) with knee OA. Subcutaneous adipose tissue was harvested by liposuction from both thighs, and arthroscopic lavage was performed, followed by ADRC injection (mean dose, 1.40 × 10(7) cells) into the synovial fluid. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score, Lysholm score, and visual analog scale score. Arthroscopic examinations were performed to assess the International Cartilage Repair Society cartilage injury grade preoperatively and overall repair postoperatively. Noninvasive assessments were performed at baseline and at 1-, 3-, and 6-month follow-ups; arthroscopic assessments were performed at baseline and at 6 months. RESULTS: All outcome measures significantly improved after treatment. This improvement was evident 1 month after treatment and was sustained until the 6-month follow-up. Data from second-look arthroscopy showed better repair in low-grade cartilage lesions than in lesions with a greater degree of damage. No patients demonstrated worsening of Kellgren-Lawrence grade, and none underwent total knee arthroplasty during this period. CONCLUSIONS: Clinical outcomes were improved in patients with knee OA after ADRC administration. Cartilage regeneration was more effective in smaller damaged lesions than in bigger lesions.
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spelling pubmed-93932842022-09-01 Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis Onoi, Yuma Hiranaka, Takafumi Hida, Yuichi Fujishiro, Takaaki Okamoto, Koji Matsumoto, Tomoyuki Kuroda, Ryosuke Clin Orthop Surg Original Article BACKGROUND: To evaluate the clinical outcomes and second-look arthroscopic findings after intra-articular adipose-derived regenerative cell (ADRC) injection as treatment for knee osteoarthritis (OA). METHODS: ADRCs were administered to 11 patients (19 knees; mean age, 61.7 years) with knee OA. Subcutaneous adipose tissue was harvested by liposuction from both thighs, and arthroscopic lavage was performed, followed by ADRC injection (mean dose, 1.40 × 10(7) cells) into the synovial fluid. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score, Lysholm score, and visual analog scale score. Arthroscopic examinations were performed to assess the International Cartilage Repair Society cartilage injury grade preoperatively and overall repair postoperatively. Noninvasive assessments were performed at baseline and at 1-, 3-, and 6-month follow-ups; arthroscopic assessments were performed at baseline and at 6 months. RESULTS: All outcome measures significantly improved after treatment. This improvement was evident 1 month after treatment and was sustained until the 6-month follow-up. Data from second-look arthroscopy showed better repair in low-grade cartilage lesions than in lesions with a greater degree of damage. No patients demonstrated worsening of Kellgren-Lawrence grade, and none underwent total knee arthroplasty during this period. CONCLUSIONS: Clinical outcomes were improved in patients with knee OA after ADRC administration. Cartilage regeneration was more effective in smaller damaged lesions than in bigger lesions. The Korean Orthopaedic Association 2022-09 2022-02-07 /pmc/articles/PMC9393284/ /pubmed/36061847 http://dx.doi.org/10.4055/cios20312 Text en Copyright © 2022 by The Korean Orthopaedic Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Onoi, Yuma
Hiranaka, Takafumi
Hida, Yuichi
Fujishiro, Takaaki
Okamoto, Koji
Matsumoto, Tomoyuki
Kuroda, Ryosuke
Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title_full Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title_fullStr Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title_full_unstemmed Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title_short Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis
title_sort second-look arthroscopic findings and clinical outcomes after adipose-derived regenerative cell injection in knee osteoarthritis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393284/
https://www.ncbi.nlm.nih.gov/pubmed/36061847
http://dx.doi.org/10.4055/cios20312
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