Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation

We present a case report of successful treatment with nirmatrelvir/ritonavir (Paxlvoid) for a severe aplastic anemia child with COVID-19, cytopenia, and mixed chimerism of donor hematopoietic cells at 3 months after allogeneic hematopoietic stem cell transplantation. After the 5-day entire course of...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jinhua, Yin, Di, Qin, Xia, Yu, Mei, Jiang, Beilei, Chen, Jing, Cao, Qing, Tang, Zhiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393292/
https://www.ncbi.nlm.nih.gov/pubmed/36003491
http://dx.doi.org/10.3389/fped.2022.935118
_version_ 1784771240203911168
author Huang, Jinhua
Yin, Di
Qin, Xia
Yu, Mei
Jiang, Beilei
Chen, Jing
Cao, Qing
Tang, Zhiguo
author_facet Huang, Jinhua
Yin, Di
Qin, Xia
Yu, Mei
Jiang, Beilei
Chen, Jing
Cao, Qing
Tang, Zhiguo
author_sort Huang, Jinhua
collection PubMed
description We present a case report of successful treatment with nirmatrelvir/ritonavir (Paxlvoid) for a severe aplastic anemia child with COVID-19, cytopenia, and mixed chimerism of donor hematopoietic cells at 3 months after allogeneic hematopoietic stem cell transplantation. After the 5-day entire course of treatment, the clinical symptoms were relieved, cycle threshold values of ORF1a/b and N genes increased from 22.60 and 22.15 to 34.52 and 33.84, respectively, and the peripheral blood counts gradually recovered without graft failure. Nirmatrelvir/ritonavir can effectively inhibit the replication of SARS-CoV-2 without any significant adverse effects.
format Online
Article
Text
id pubmed-9393292
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93932922022-08-23 Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation Huang, Jinhua Yin, Di Qin, Xia Yu, Mei Jiang, Beilei Chen, Jing Cao, Qing Tang, Zhiguo Front Pediatr Pediatrics We present a case report of successful treatment with nirmatrelvir/ritonavir (Paxlvoid) for a severe aplastic anemia child with COVID-19, cytopenia, and mixed chimerism of donor hematopoietic cells at 3 months after allogeneic hematopoietic stem cell transplantation. After the 5-day entire course of treatment, the clinical symptoms were relieved, cycle threshold values of ORF1a/b and N genes increased from 22.60 and 22.15 to 34.52 and 33.84, respectively, and the peripheral blood counts gradually recovered without graft failure. Nirmatrelvir/ritonavir can effectively inhibit the replication of SARS-CoV-2 without any significant adverse effects. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393292/ /pubmed/36003491 http://dx.doi.org/10.3389/fped.2022.935118 Text en Copyright © 2022 Huang, Yin, Qin, Yu, Jiang, Chen, Cao and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Huang, Jinhua
Yin, Di
Qin, Xia
Yu, Mei
Jiang, Beilei
Chen, Jing
Cao, Qing
Tang, Zhiguo
Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title_full Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title_fullStr Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title_short Case report: Application of nirmatrelvir/ritonavir to treat COVID-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
title_sort case report: application of nirmatrelvir/ritonavir to treat covid-19 in a severe aplastic anemia child after allogeneic hematopoietic stem cell transplantation
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393292/
https://www.ncbi.nlm.nih.gov/pubmed/36003491
http://dx.doi.org/10.3389/fped.2022.935118
work_keys_str_mv AT huangjinhua casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT yindi casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT qinxia casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT yumei casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT jiangbeilei casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT chenjing casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT caoqing casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation
AT tangzhiguo casereportapplicationofnirmatrelvirritonavirtotreatcovid19inasevereaplasticanemiachildafterallogeneichematopoieticstemcelltransplantation

Ejemplares similares