Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progres...

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Autores principales: Wu, Jinchun, Liu, Yanmin, Wei, Xiaojuan, Zhang, Xiaofei, Ye, Yi, Li, Wei, Su, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393294/
https://www.ncbi.nlm.nih.gov/pubmed/36003915
http://dx.doi.org/10.3389/fcvm.2022.915455
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author Wu, Jinchun
Liu, Yanmin
Wei, Xiaojuan
Zhang, Xiaofei
Ye, Yi
Li, Wei
Su, Xiaoling
author_facet Wu, Jinchun
Liu, Yanmin
Wei, Xiaojuan
Zhang, Xiaofei
Ye, Yi
Li, Wei
Su, Xiaoling
author_sort Wu, Jinchun
collection PubMed
description Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progression of chronic kidney disease. In addition, recent basic and clinical studies have also reported that SGLT2i also has good anti-arrhythmic effects. However, the exact mechanism is poorly understood. The aim of this review is to summarize recent clinical findings, studies of laboratory animals, and related study about this aspect of the antiarrhythmic effects of SGLT2i, to further explore its underlying mechanisms, safety, and prospects for clinical applications of it.
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spelling pubmed-93932942022-08-23 Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review Wu, Jinchun Liu, Yanmin Wei, Xiaojuan Zhang, Xiaofei Ye, Yi Li, Wei Su, Xiaoling Front Cardiovasc Med Cardiovascular Medicine Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart failure, cardiovascular death, and delay the progression of chronic kidney disease. In addition, recent basic and clinical studies have also reported that SGLT2i also has good anti-arrhythmic effects. However, the exact mechanism is poorly understood. The aim of this review is to summarize recent clinical findings, studies of laboratory animals, and related study about this aspect of the antiarrhythmic effects of SGLT2i, to further explore its underlying mechanisms, safety, and prospects for clinical applications of it. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393294/ /pubmed/36003915 http://dx.doi.org/10.3389/fcvm.2022.915455 Text en Copyright © 2022 Wu, Liu, Wei, Zhang, Ye, Li and Su. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wu, Jinchun
Liu, Yanmin
Wei, Xiaojuan
Zhang, Xiaofei
Ye, Yi
Li, Wei
Su, Xiaoling
Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title_full Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title_fullStr Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title_full_unstemmed Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title_short Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
title_sort antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: a mini review
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393294/
https://www.ncbi.nlm.nih.gov/pubmed/36003915
http://dx.doi.org/10.3389/fcvm.2022.915455
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