Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature

Facial and neck erythema secondary to dupilumab use is a side effect not reported in clinical trials; however, it has been reported aftermarket initially in adults and most recently in adolescents. We report the youngest known case of head and neck dermatitis (HND) secondary to Malassezia furfur acc...

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Autores principales: Samia, Arthur M, Cuervo-Pardo, Lyda, Montanez-Wiscovich, Marjorie E, Cavero-Chavez, Vanessa Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393337/
https://www.ncbi.nlm.nih.gov/pubmed/36017279
http://dx.doi.org/10.7759/cureus.27170
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author Samia, Arthur M
Cuervo-Pardo, Lyda
Montanez-Wiscovich, Marjorie E
Cavero-Chavez, Vanessa Y
author_facet Samia, Arthur M
Cuervo-Pardo, Lyda
Montanez-Wiscovich, Marjorie E
Cavero-Chavez, Vanessa Y
author_sort Samia, Arthur M
collection PubMed
description Facial and neck erythema secondary to dupilumab use is a side effect not reported in clinical trials; however, it has been reported aftermarket initially in adults and most recently in adolescents. We report the youngest known case of head and neck dermatitis (HND) secondary to Malassezia furfur accompanied by ocular involvement. Treatment with oral fluconazole 150 mg weekly was initiated with subsequent cutaneous improvement. Additionally, his conjunctivitis improved with fluorometholone 0.1% eye drops. As dupilumab becomes more accessible to children, understanding the pathophysiology of HND, characterizing the clinical course, and developing diagnostic and treatment guidelines for this age group will be imperative.
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spelling pubmed-93933372022-08-24 Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature Samia, Arthur M Cuervo-Pardo, Lyda Montanez-Wiscovich, Marjorie E Cavero-Chavez, Vanessa Y Cureus Dermatology Facial and neck erythema secondary to dupilumab use is a side effect not reported in clinical trials; however, it has been reported aftermarket initially in adults and most recently in adolescents. We report the youngest known case of head and neck dermatitis (HND) secondary to Malassezia furfur accompanied by ocular involvement. Treatment with oral fluconazole 150 mg weekly was initiated with subsequent cutaneous improvement. Additionally, his conjunctivitis improved with fluorometholone 0.1% eye drops. As dupilumab becomes more accessible to children, understanding the pathophysiology of HND, characterizing the clinical course, and developing diagnostic and treatment guidelines for this age group will be imperative. Cureus 2022-07-23 /pmc/articles/PMC9393337/ /pubmed/36017279 http://dx.doi.org/10.7759/cureus.27170 Text en Copyright © 2022, Samia et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Samia, Arthur M
Cuervo-Pardo, Lyda
Montanez-Wiscovich, Marjorie E
Cavero-Chavez, Vanessa Y
Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title_full Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title_fullStr Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title_full_unstemmed Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title_short Dupilumab-Associated Head and Neck Dermatitis With Ocular Involvement in a Ten-Year-Old With Atopic Dermatitis: A Case Report and Review of the Literature
title_sort dupilumab-associated head and neck dermatitis with ocular involvement in a ten-year-old with atopic dermatitis: a case report and review of the literature
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393337/
https://www.ncbi.nlm.nih.gov/pubmed/36017279
http://dx.doi.org/10.7759/cureus.27170
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