Cargando…
TGF-β regulates the stem-like state of PD-1(+) TCF-1(+) virus-specific CD8 T cells during chronic infection
Recent studies have defined a novel population of PD-1(+) TCF-1(+) stem-like CD8 T cells in chronic infections and cancer. These quiescent cells reside in lymphoid tissues, are critical for maintaining the CD8 T cell response under conditions of persistent antigen, and provide the proliferative burs...
Autores principales: | Hu, Yinghong, Hudson, William H., Kissick, Haydn T., Medina, Christopher B., Baptista, Antonio P., Ma, Chaoyu, Liao, Wei, Germain, Ronald N., Turley, Shannon J., Zhang, Nu, Ahmed, Rafi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393409/ https://www.ncbi.nlm.nih.gov/pubmed/35980386 http://dx.doi.org/10.1084/jem.20211574 |
Ejemplares similares
-
Lymphoid tissue residency: A key to understand Tcf-1(+)PD-1(+) T cells
por: Ma, Chaoyu, et al.
Publicado: (2022) -
Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
por: Im, Se Jin, et al.
Publicado: (2023) -
Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade
por: Jadhav, Rohit R., et al.
Publicado: (2019) -
Expression of novel long noncoding RNAs defines virus-specific effector and memory CD8(+) T cells
por: Hudson, William H., et al.
Publicado: (2019) -
TGF-β and Eomes control the homeostasis of CD8(+) regulatory T cells
por: Mishra, Shruti, et al.
Publicado: (2020)