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Phenotypic screening of low molecular weight compounds is rich ground for repurposed, on-target drugs
A target-based drug discovery strategy has led to a bias away from low molecular weight (MWT) drug discovery. Analysis of the ACS chemistry registration system shows that most low MWT drugs were first made in the time era before target-based drug discovery. Therapeutic activity among most low MWT dr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393533/ https://www.ncbi.nlm.nih.gov/pubmed/36003497 http://dx.doi.org/10.3389/fphar.2022.917968 |