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Detecting bacterial adaptation within individual microbiomes

The human microbiome harbours a large capacity for within-person adaptive mutations. Commensal bacterial strains can stably colonize a person for decades, and billions of mutations are generated daily within each person's microbiome. Adaptive mutations emerging during health might be driven by...

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Autor principal: Lieberman, Tami D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393564/
https://www.ncbi.nlm.nih.gov/pubmed/35989602
http://dx.doi.org/10.1098/rstb.2021.0243
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author Lieberman, Tami D.
author_facet Lieberman, Tami D.
author_sort Lieberman, Tami D.
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description The human microbiome harbours a large capacity for within-person adaptive mutations. Commensal bacterial strains can stably colonize a person for decades, and billions of mutations are generated daily within each person's microbiome. Adaptive mutations emerging during health might be driven by selective forces that vary across individuals, vary within an individual, or are completely novel to the human population. Mutations emerging within individual microbiomes might impact the immune system, the metabolism of nutrients or drugs, and the stability of the community to perturbations. Despite this potential, relatively little attention has been paid to the possibility of adaptive evolution within complex human-associated microbiomes. This review discusses the promise of studying within-microbiome adaptation, the conceptual and technical limitations that may have contributed to an underappreciation of adaptive de novo mutations occurring within microbiomes to date, and methods for detecting recent adaptive evolution. This article is part of a discussion meeting issue ‘Genomic population structures of microbial pathogens’.
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spelling pubmed-93935642022-08-30 Detecting bacterial adaptation within individual microbiomes Lieberman, Tami D. Philos Trans R Soc Lond B Biol Sci Articles The human microbiome harbours a large capacity for within-person adaptive mutations. Commensal bacterial strains can stably colonize a person for decades, and billions of mutations are generated daily within each person's microbiome. Adaptive mutations emerging during health might be driven by selective forces that vary across individuals, vary within an individual, or are completely novel to the human population. Mutations emerging within individual microbiomes might impact the immune system, the metabolism of nutrients or drugs, and the stability of the community to perturbations. Despite this potential, relatively little attention has been paid to the possibility of adaptive evolution within complex human-associated microbiomes. This review discusses the promise of studying within-microbiome adaptation, the conceptual and technical limitations that may have contributed to an underappreciation of adaptive de novo mutations occurring within microbiomes to date, and methods for detecting recent adaptive evolution. This article is part of a discussion meeting issue ‘Genomic population structures of microbial pathogens’. The Royal Society 2022-10-10 2022-08-22 /pmc/articles/PMC9393564/ /pubmed/35989602 http://dx.doi.org/10.1098/rstb.2021.0243 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
Lieberman, Tami D.
Detecting bacterial adaptation within individual microbiomes
title Detecting bacterial adaptation within individual microbiomes
title_full Detecting bacterial adaptation within individual microbiomes
title_fullStr Detecting bacterial adaptation within individual microbiomes
title_full_unstemmed Detecting bacterial adaptation within individual microbiomes
title_short Detecting bacterial adaptation within individual microbiomes
title_sort detecting bacterial adaptation within individual microbiomes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393564/
https://www.ncbi.nlm.nih.gov/pubmed/35989602
http://dx.doi.org/10.1098/rstb.2021.0243
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