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Hepatitis of unknown etiology in children: What we know and what we can do?

Recently, acute hepatitis of unknown etiology in children has gained great concern since March 2022. The disease was first reported by Public Health Scotland. Cases increased rapidly and are now reported in 33 countries worldwide. All cases are predominantly aged under 5 years old. Most patients pre...

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Detalles Bibliográficos
Autores principales: Zhu, Mingyu, Chen, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393628/
https://www.ncbi.nlm.nih.gov/pubmed/36003929
http://dx.doi.org/10.3389/fmicb.2022.956887
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author Zhu, Mingyu
Chen, Li
author_facet Zhu, Mingyu
Chen, Li
author_sort Zhu, Mingyu
collection PubMed
description Recently, acute hepatitis of unknown etiology in children has gained great concern since March 2022. The disease was first reported by Public Health Scotland. Cases increased rapidly and are now reported in 33 countries worldwide. All cases are predominantly aged under 5 years old. Most patients presented with jaundice, and remarkably, some cases progress to acute liver failure. Until now, the etiology is not fully elucidated, and the investigations are ongoing. Adenovirus infection seems to be an important factor. Several hypotheses on the etiology have been proposed. This review aims to summarize current research progress and put forward some suggestions.
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spelling pubmed-93936282022-08-23 Hepatitis of unknown etiology in children: What we know and what we can do? Zhu, Mingyu Chen, Li Front Microbiol Microbiology Recently, acute hepatitis of unknown etiology in children has gained great concern since March 2022. The disease was first reported by Public Health Scotland. Cases increased rapidly and are now reported in 33 countries worldwide. All cases are predominantly aged under 5 years old. Most patients presented with jaundice, and remarkably, some cases progress to acute liver failure. Until now, the etiology is not fully elucidated, and the investigations are ongoing. Adenovirus infection seems to be an important factor. Several hypotheses on the etiology have been proposed. This review aims to summarize current research progress and put forward some suggestions. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393628/ /pubmed/36003929 http://dx.doi.org/10.3389/fmicb.2022.956887 Text en Copyright © 2022 Zhu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhu, Mingyu
Chen, Li
Hepatitis of unknown etiology in children: What we know and what we can do?
title Hepatitis of unknown etiology in children: What we know and what we can do?
title_full Hepatitis of unknown etiology in children: What we know and what we can do?
title_fullStr Hepatitis of unknown etiology in children: What we know and what we can do?
title_full_unstemmed Hepatitis of unknown etiology in children: What we know and what we can do?
title_short Hepatitis of unknown etiology in children: What we know and what we can do?
title_sort hepatitis of unknown etiology in children: what we know and what we can do?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393628/
https://www.ncbi.nlm.nih.gov/pubmed/36003929
http://dx.doi.org/10.3389/fmicb.2022.956887
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