Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A single nucleotide polymorphism of GFI1, GFI1-36N, has a prevalence of 7% in healthy Caucasians and 15% in acute myeloid leukemia (AML) patients,...

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Detalles Bibliográficos
Autores principales: Vorwerk, Jan, Sun, Kaiyan, Frank, Daria, Neumann, Felix, Hüve, Jana, Budde, Paulina Marie, Liu, Longlong, Xie, Xiaoqing, Patnana, Pradeep Kumar, Ahmed, Helal Mohammed Mohammed, Opalka, Bertram, Lenz, Georg, Jayavelu, Ashok Kumar, Khandanpour, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393725/
https://www.ncbi.nlm.nih.gov/pubmed/36003783
http://dx.doi.org/10.3389/fonc.2022.903691

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