The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis

Here we show that soluble CD83 induces the resolution of inflammation in an antigen-induced arthritis (AIA) model. Joint swelling and the arthritis-related expression levels of IL-1β, IL-6, RANKL, MMP9, and OC-Stamp were strongly reduced, while Foxp3 was induced. In addition, we observed a significa...

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Detalles Bibliográficos
Autores principales: Royzman, Dmytro, Andreev, Darja, Stich, Lena, Peckert-Maier, Katrin, Wild, Andreas B., Zinser, Elisabeth, Mühl-Zürbes, Petra, Jones, Evan, Adam, Susanne, Frey, Silke, Fuchs, Maximilian, Kunz, Meik, Bäuerle, Tobias, Nagel, Lisa, Schett, Georg, Bozec, Aline, Steinkasserer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393726/
https://www.ncbi.nlm.nih.gov/pubmed/36003376
http://dx.doi.org/10.3389/fimmu.2022.936995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393726/
https://www.ncbi.nlm.nih.gov/pubmed/36003376
http://dx.doi.org/10.3389/fimmu.2022.936995

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