Proton therapy in the treatment of hepatocellular carcinoma

Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced...

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Autores principales: Dionisi, Francesco, Scartoni, Daniele, Fracchiolla, Francesco, Giacomelli, Irene, Siniscalchi, Benedetta, Goanta, Lucia, Cianchetti, Marco, Sanguineti, Giuseppe, Brolese, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393743/
https://www.ncbi.nlm.nih.gov/pubmed/36003769
http://dx.doi.org/10.3389/fonc.2022.959552
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author Dionisi, Francesco
Scartoni, Daniele
Fracchiolla, Francesco
Giacomelli, Irene
Siniscalchi, Benedetta
Goanta, Lucia
Cianchetti, Marco
Sanguineti, Giuseppe
Brolese, Alberto
author_facet Dionisi, Francesco
Scartoni, Daniele
Fracchiolla, Francesco
Giacomelli, Irene
Siniscalchi, Benedetta
Goanta, Lucia
Cianchetti, Marco
Sanguineti, Giuseppe
Brolese, Alberto
author_sort Dionisi, Francesco
collection PubMed
description Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced radiation therapy technique with unique physical properties which fit well with liver irradiation. Here, in this review, we aim to 1) illustrate the rationale for the use of proton therapy (PT) in the treatment of HCC, 2) discuss the technical challenges of advanced PT in this disease, 3) review the major clinical studies regarding the use of PT for HCC, and 4) analyze the potential developments and future directions of PT in this setting.
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spelling pubmed-93937432022-08-23 Proton therapy in the treatment of hepatocellular carcinoma Dionisi, Francesco Scartoni, Daniele Fracchiolla, Francesco Giacomelli, Irene Siniscalchi, Benedetta Goanta, Lucia Cianchetti, Marco Sanguineti, Giuseppe Brolese, Alberto Front Oncol Oncology Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced radiation therapy technique with unique physical properties which fit well with liver irradiation. Here, in this review, we aim to 1) illustrate the rationale for the use of proton therapy (PT) in the treatment of HCC, 2) discuss the technical challenges of advanced PT in this disease, 3) review the major clinical studies regarding the use of PT for HCC, and 4) analyze the potential developments and future directions of PT in this setting. Frontiers Media S.A. 2022-08-08 /pmc/articles/PMC9393743/ /pubmed/36003769 http://dx.doi.org/10.3389/fonc.2022.959552 Text en Copyright © 2022 Dionisi, Scartoni, Fracchiolla, Giacomelli, Siniscalchi, Goanta, Cianchetti, Sanguineti and Brolese https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dionisi, Francesco
Scartoni, Daniele
Fracchiolla, Francesco
Giacomelli, Irene
Siniscalchi, Benedetta
Goanta, Lucia
Cianchetti, Marco
Sanguineti, Giuseppe
Brolese, Alberto
Proton therapy in the treatment of hepatocellular carcinoma
title Proton therapy in the treatment of hepatocellular carcinoma
title_full Proton therapy in the treatment of hepatocellular carcinoma
title_fullStr Proton therapy in the treatment of hepatocellular carcinoma
title_full_unstemmed Proton therapy in the treatment of hepatocellular carcinoma
title_short Proton therapy in the treatment of hepatocellular carcinoma
title_sort proton therapy in the treatment of hepatocellular carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393743/
https://www.ncbi.nlm.nih.gov/pubmed/36003769
http://dx.doi.org/10.3389/fonc.2022.959552
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