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Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254–290) in Alzheimer’s Disease: A Molecular Dynamics Simulation Study
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose early diagnosis leads to a chance for successful treatment and decreases the side effects. Hyperphosphorylation of tau proteins is a pathological hallmark of AD that causes it to lose its attachment ability to the microtubule...
Autores principales: | Alipour, Mozhgan, Motavaf, Mahsa, Abdolmaleki, Parviz, Zali, Alireza, Ashrafi, Farzad, Safari, Saeid, Hajipour-Verdom, Behnam |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393928/ https://www.ncbi.nlm.nih.gov/pubmed/36003083 http://dx.doi.org/10.3389/fmolb.2022.884705 |
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