Structural Analysis and Conformational Dynamics of Short Helical Hyperphosphorylated Segments of Tau Protein (Sequence 254–290) in Alzheimer’s Disease: A Molecular Dynamics Simulation Study

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose early diagnosis leads to a chance for successful treatment and decreases the side effects. Hyperphosphorylation of tau proteins is a pathological hallmark of AD that causes it to lose its attachment ability to the microtubule...

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Detalles Bibliográficos
Autores principales: Alipour, Mozhgan, Motavaf, Mahsa, Abdolmaleki, Parviz, Zali, Alireza, Ashrafi, Farzad, Safari, Saeid, Hajipour-Verdom, Behnam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393928/
https://www.ncbi.nlm.nih.gov/pubmed/36003083
http://dx.doi.org/10.3389/fmolb.2022.884705

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