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Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities

BACKGROUND: Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determine TL in patients with severe COVID-19 requiring hospitalization to analyze whe...

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Autores principales: Retuerto, Miriam, Lledó, Ana, Fernandez-Varas, Beatriz, Guerrero-López, Rosa, Usategui, Alicia, Lalueza, Antonio, García-García, Rocío, Mancebo, Esther, Paz-Artal, Estela, Sastre, Leandro, Perona, Rosario, Pablos, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394033/
https://www.ncbi.nlm.nih.gov/pubmed/35996190
http://dx.doi.org/10.1186/s12979-022-00294-9
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author Retuerto, Miriam
Lledó, Ana
Fernandez-Varas, Beatriz
Guerrero-López, Rosa
Usategui, Alicia
Lalueza, Antonio
García-García, Rocío
Mancebo, Esther
Paz-Artal, Estela
Sastre, Leandro
Perona, Rosario
Pablos, José L.
author_facet Retuerto, Miriam
Lledó, Ana
Fernandez-Varas, Beatriz
Guerrero-López, Rosa
Usategui, Alicia
Lalueza, Antonio
García-García, Rocío
Mancebo, Esther
Paz-Artal, Estela
Sastre, Leandro
Perona, Rosario
Pablos, José L.
author_sort Retuerto, Miriam
collection PubMed
description BACKGROUND: Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determine TL in patients with severe COVID-19 requiring hospitalization to analyze whether clinical outcomes and post-COVID-19 manifestations are associated with shorter TL. RESULTS: We analyzed 251 patients with PCR-confirmed COVID-19, hospitalized in the first months of the pandemics. We determined TL in PBL at admission by quantitative-PCR (qPCR) analysis in patients. A healthy cohort from the same area with a similar age range (n = 169) was used to calculate TL Z-scores. After hospital discharge, 144 COVID-19 survivors were followed-up for persistent COVID-19 manifestations. A second TL determination was performed in a smaller group of 63 patients 1 year later and compared with baseline TL. Hospitalized COVID-19 patients had a decreased baseline age-adjusted TL Z-score compared to the reference group. No differences in Z-scores were observed in patients with different COVID-19 outcomes, classified as WHO ordinal scores. In 144 patients, followed for a median of 8 months, post-COVID manifestations were not associated to differences in TL. Persistence of lung radiographic abnormalities was associated with shorter baseline TL. In patients with a second TL determination, further telomere shortening (TS) was observed in 35% and telomere lengthening in 49%. Patients with further TS had suffered a more severe disease. CONCLUSION: Shorter TL is associated with COVID-19 hospitalization but not with hospital clinical outcomes nor with persistent post-COVID-19 manifestations. Delayed resolution of radiographic lung abnormalities was also associated with shorter TL.
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spelling pubmed-93940332022-08-23 Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities Retuerto, Miriam Lledó, Ana Fernandez-Varas, Beatriz Guerrero-López, Rosa Usategui, Alicia Lalueza, Antonio García-García, Rocío Mancebo, Esther Paz-Artal, Estela Sastre, Leandro Perona, Rosario Pablos, José L. Immun Ageing Research BACKGROUND: Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determine TL in patients with severe COVID-19 requiring hospitalization to analyze whether clinical outcomes and post-COVID-19 manifestations are associated with shorter TL. RESULTS: We analyzed 251 patients with PCR-confirmed COVID-19, hospitalized in the first months of the pandemics. We determined TL in PBL at admission by quantitative-PCR (qPCR) analysis in patients. A healthy cohort from the same area with a similar age range (n = 169) was used to calculate TL Z-scores. After hospital discharge, 144 COVID-19 survivors were followed-up for persistent COVID-19 manifestations. A second TL determination was performed in a smaller group of 63 patients 1 year later and compared with baseline TL. Hospitalized COVID-19 patients had a decreased baseline age-adjusted TL Z-score compared to the reference group. No differences in Z-scores were observed in patients with different COVID-19 outcomes, classified as WHO ordinal scores. In 144 patients, followed for a median of 8 months, post-COVID manifestations were not associated to differences in TL. Persistence of lung radiographic abnormalities was associated with shorter baseline TL. In patients with a second TL determination, further telomere shortening (TS) was observed in 35% and telomere lengthening in 49%. Patients with further TS had suffered a more severe disease. CONCLUSION: Shorter TL is associated with COVID-19 hospitalization but not with hospital clinical outcomes nor with persistent post-COVID-19 manifestations. Delayed resolution of radiographic lung abnormalities was also associated with shorter TL. BioMed Central 2022-08-22 /pmc/articles/PMC9394033/ /pubmed/35996190 http://dx.doi.org/10.1186/s12979-022-00294-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Retuerto, Miriam
Lledó, Ana
Fernandez-Varas, Beatriz
Guerrero-López, Rosa
Usategui, Alicia
Lalueza, Antonio
García-García, Rocío
Mancebo, Esther
Paz-Artal, Estela
Sastre, Leandro
Perona, Rosario
Pablos, José L.
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title_full Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title_fullStr Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title_full_unstemmed Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title_short Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities
title_sort shorter telomere length is associated with covid-19 hospitalization and with persistence of radiographic lung abnormalities
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394033/
https://www.ncbi.nlm.nih.gov/pubmed/35996190
http://dx.doi.org/10.1186/s12979-022-00294-9
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