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Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge

Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephali...

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Autores principales: Ansari, Farzana, Budania, Anil, Rao, Meenakshi, Yadav, Taruna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394199/
https://www.ncbi.nlm.nih.gov/pubmed/35981749
http://dx.doi.org/10.1136/bcr-2021-247694
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author Ansari, Farzana
Budania, Anil
Rao, Meenakshi
Yadav, Taruna
author_facet Ansari, Farzana
Budania, Anil
Rao, Meenakshi
Yadav, Taruna
author_sort Ansari, Farzana
collection PubMed
description Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephalitis, actinomycetoma, subdural empyema and epidural abscess. We report one case of extensive actinomycosis having intra and extraparenchymal CNS, spinal canal, retropharyngeal and mediastinal involvement. Due to such widespread extension and involvement of vital areas, complete surgical debulking was not possible. In addition to therapeutic resistance to conventional antibiotics, repetitive negative cultures posed significant difficulty in the case management.
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spelling pubmed-93941992022-09-06 Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge Ansari, Farzana Budania, Anil Rao, Meenakshi Yadav, Taruna BMJ Case Rep Case Reports: Rare disease Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephalitis, actinomycetoma, subdural empyema and epidural abscess. We report one case of extensive actinomycosis having intra and extraparenchymal CNS, spinal canal, retropharyngeal and mediastinal involvement. Due to such widespread extension and involvement of vital areas, complete surgical debulking was not possible. In addition to therapeutic resistance to conventional antibiotics, repetitive negative cultures posed significant difficulty in the case management. BMJ Publishing Group 2022-08-18 /pmc/articles/PMC9394199/ /pubmed/35981749 http://dx.doi.org/10.1136/bcr-2021-247694 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Rare disease
Ansari, Farzana
Budania, Anil
Rao, Meenakshi
Yadav, Taruna
Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title_full Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title_fullStr Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title_full_unstemmed Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title_short Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
title_sort extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
topic Case Reports: Rare disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394199/
https://www.ncbi.nlm.nih.gov/pubmed/35981749
http://dx.doi.org/10.1136/bcr-2021-247694
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