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Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge
Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephali...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394199/ https://www.ncbi.nlm.nih.gov/pubmed/35981749 http://dx.doi.org/10.1136/bcr-2021-247694 |
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author | Ansari, Farzana Budania, Anil Rao, Meenakshi Yadav, Taruna |
author_facet | Ansari, Farzana Budania, Anil Rao, Meenakshi Yadav, Taruna |
author_sort | Ansari, Farzana |
collection | PubMed |
description | Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephalitis, actinomycetoma, subdural empyema and epidural abscess. We report one case of extensive actinomycosis having intra and extraparenchymal CNS, spinal canal, retropharyngeal and mediastinal involvement. Due to such widespread extension and involvement of vital areas, complete surgical debulking was not possible. In addition to therapeutic resistance to conventional antibiotics, repetitive negative cultures posed significant difficulty in the case management. |
format | Online Article Text |
id | pubmed-9394199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-93941992022-09-06 Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge Ansari, Farzana Budania, Anil Rao, Meenakshi Yadav, Taruna BMJ Case Rep Case Reports: Rare disease Central nervous system (CNS) involvement by actinomycosis is rare, seen in 2%–3% cases. It mostly spreads to CNS by haematogenous route from a distant primary site such as oral cavity, lung, abdomen or pelvis. Direct CNS extension can also occur. It mostly presents as brain abscess, meningoencephalitis, actinomycetoma, subdural empyema and epidural abscess. We report one case of extensive actinomycosis having intra and extraparenchymal CNS, spinal canal, retropharyngeal and mediastinal involvement. Due to such widespread extension and involvement of vital areas, complete surgical debulking was not possible. In addition to therapeutic resistance to conventional antibiotics, repetitive negative cultures posed significant difficulty in the case management. BMJ Publishing Group 2022-08-18 /pmc/articles/PMC9394199/ /pubmed/35981749 http://dx.doi.org/10.1136/bcr-2021-247694 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. |
spellingShingle | Case Reports: Rare disease Ansari, Farzana Budania, Anil Rao, Meenakshi Yadav, Taruna Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title | Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title_full | Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title_fullStr | Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title_full_unstemmed | Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title_short | Extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
title_sort | extensive actinomycosis with intracranial and mediastinal involvement: a therapeutic challenge |
topic | Case Reports: Rare disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394199/ https://www.ncbi.nlm.nih.gov/pubmed/35981749 http://dx.doi.org/10.1136/bcr-2021-247694 |
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