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Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study

This study provides updated information on the prevalence and co-infections caused by genital microorganisms and pathogens: Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, Trichomonas vaginalis, and Gardnerella vaginalis, by retrospectively analyzing a cohort of...

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Autores principales: Scaglione, Elena, Mantova, Giuseppe, Caturano, Valeria, Fanasca, Luca, Carraturo, Francesca, Farina, Fabrizio, Pagliarulo, Caterina, Vitiello, Mariateresa, Pagliuca, Chiara, Salvatore, Paola, Colicchio, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394247/
https://www.ncbi.nlm.nih.gov/pubmed/35892509
http://dx.doi.org/10.3390/diagnostics12081798
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author Scaglione, Elena
Mantova, Giuseppe
Caturano, Valeria
Fanasca, Luca
Carraturo, Francesca
Farina, Fabrizio
Pagliarulo, Caterina
Vitiello, Mariateresa
Pagliuca, Chiara
Salvatore, Paola
Colicchio, Roberta
author_facet Scaglione, Elena
Mantova, Giuseppe
Caturano, Valeria
Fanasca, Luca
Carraturo, Francesca
Farina, Fabrizio
Pagliarulo, Caterina
Vitiello, Mariateresa
Pagliuca, Chiara
Salvatore, Paola
Colicchio, Roberta
author_sort Scaglione, Elena
collection PubMed
description This study provides updated information on the prevalence and co-infections caused by genital microorganisms and pathogens: Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, Trichomonas vaginalis, and Gardnerella vaginalis, by retrospectively analyzing a cohort of patients living in the Naples metropolitan area, Campania region, Southern Italy. To investigate the genital infections prevalence in clinical specimens (vaginal/endocervical swabs and urines) collected from infertile asymptomatic women and men from November 2018 to December 2020, we used a multiplex real-time PCR assay. Of the 717 specimens collected, 302 (42.1%) resulted positive for at least one of the targets named above. Statistically significant differences in genital prevalence of selected microorganisms were detected in both women (62.91%) and men (37.08%). G. vaginalis and U. parvum represented the most common findings with an 80.2% and 16.9% prevalence in vaginal/endocervical swabs and first-voided urines, respectively. Prevalence of multiple infections was 18.18% and 8.19% in women and men, respectively. The most frequent association detected was the co-infection of G. vaginalis and U. parvum with 60% prevalence. Our epidemiological analysis suggests different infection patterns between genders, highlighting the need to implement a preventative screening strategy of genital infections to reduce the complications on reproductive organs.
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spelling pubmed-93942472022-08-23 Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study Scaglione, Elena Mantova, Giuseppe Caturano, Valeria Fanasca, Luca Carraturo, Francesca Farina, Fabrizio Pagliarulo, Caterina Vitiello, Mariateresa Pagliuca, Chiara Salvatore, Paola Colicchio, Roberta Diagnostics (Basel) Article This study provides updated information on the prevalence and co-infections caused by genital microorganisms and pathogens: Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, Ureaplasma urealyticum, Trichomonas vaginalis, and Gardnerella vaginalis, by retrospectively analyzing a cohort of patients living in the Naples metropolitan area, Campania region, Southern Italy. To investigate the genital infections prevalence in clinical specimens (vaginal/endocervical swabs and urines) collected from infertile asymptomatic women and men from November 2018 to December 2020, we used a multiplex real-time PCR assay. Of the 717 specimens collected, 302 (42.1%) resulted positive for at least one of the targets named above. Statistically significant differences in genital prevalence of selected microorganisms were detected in both women (62.91%) and men (37.08%). G. vaginalis and U. parvum represented the most common findings with an 80.2% and 16.9% prevalence in vaginal/endocervical swabs and first-voided urines, respectively. Prevalence of multiple infections was 18.18% and 8.19% in women and men, respectively. The most frequent association detected was the co-infection of G. vaginalis and U. parvum with 60% prevalence. Our epidemiological analysis suggests different infection patterns between genders, highlighting the need to implement a preventative screening strategy of genital infections to reduce the complications on reproductive organs. MDPI 2022-07-25 /pmc/articles/PMC9394247/ /pubmed/35892509 http://dx.doi.org/10.3390/diagnostics12081798 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scaglione, Elena
Mantova, Giuseppe
Caturano, Valeria
Fanasca, Luca
Carraturo, Francesca
Farina, Fabrizio
Pagliarulo, Caterina
Vitiello, Mariateresa
Pagliuca, Chiara
Salvatore, Paola
Colicchio, Roberta
Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title_full Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title_fullStr Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title_full_unstemmed Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title_short Molecular Epidemiology of Genital Infections in Campania Region: A Retrospective Study
title_sort molecular epidemiology of genital infections in campania region: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394247/
https://www.ncbi.nlm.nih.gov/pubmed/35892509
http://dx.doi.org/10.3390/diagnostics12081798
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