Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respirat...

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Autores principales: Bénit, Paule, Goncalves, Judith, El Khoury, Riyad, Rak, Malgorzata, Favier, Judith, Gimenez-Roqueplo, Anne-Paule, Rustin, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394281/
https://www.ncbi.nlm.nih.gov/pubmed/35892689
http://dx.doi.org/10.3390/biomedicines10081788
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author Bénit, Paule
Goncalves, Judith
El Khoury, Riyad
Rak, Malgorzata
Favier, Judith
Gimenez-Roqueplo, Anne-Paule
Rustin, Pierre
author_facet Bénit, Paule
Goncalves, Judith
El Khoury, Riyad
Rak, Malgorzata
Favier, Judith
Gimenez-Roqueplo, Anne-Paule
Rustin, Pierre
author_sort Bénit, Paule
collection PubMed
description Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.
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spelling pubmed-93942812022-08-23 Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad Bénit, Paule Goncalves, Judith El Khoury, Riyad Rak, Malgorzata Favier, Judith Gimenez-Roqueplo, Anne-Paule Rustin, Pierre Biomedicines Review Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides. MDPI 2022-07-25 /pmc/articles/PMC9394281/ /pubmed/35892689 http://dx.doi.org/10.3390/biomedicines10081788 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bénit, Paule
Goncalves, Judith
El Khoury, Riyad
Rak, Malgorzata
Favier, Judith
Gimenez-Roqueplo, Anne-Paule
Rustin, Pierre
Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title_full Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title_fullStr Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title_full_unstemmed Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title_short Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad
title_sort succinate dehydrogenase, succinate, and superoxides: a genetic, epigenetic, metabolic, environmental explosive crossroad
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394281/
https://www.ncbi.nlm.nih.gov/pubmed/35892689
http://dx.doi.org/10.3390/biomedicines10081788
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