Cargando…

Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis

Poly(acrylic acid) (PAA) is a water-soluble synthetic polymer that exhibits bioadhesive properties and has been applied in various novel medical devices, such as drug-delivery carriers and hemostatic agents. PAA forms a water-insoluble complex when mixed with polyvinylpyrrolidone (PVP). If PAA and P...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Tomoko, Yamaguchi, Shingo, Soga, Daisuke, Yoshimoto, Takayuki, Koyama, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394286/
https://www.ncbi.nlm.nih.gov/pubmed/35892721
http://dx.doi.org/10.3390/gels8080462
_version_ 1784771455259508736
author Ito, Tomoko
Yamaguchi, Shingo
Soga, Daisuke
Yoshimoto, Takayuki
Koyama, Yoshiyuki
author_facet Ito, Tomoko
Yamaguchi, Shingo
Soga, Daisuke
Yoshimoto, Takayuki
Koyama, Yoshiyuki
author_sort Ito, Tomoko
collection PubMed
description Poly(acrylic acid) (PAA) is a water-soluble synthetic polymer that exhibits bioadhesive properties and has been applied in various novel medical devices, such as drug-delivery carriers and hemostatic agents. PAA forms a water-insoluble complex when mixed with polyvinylpyrrolidone (PVP). If PAA and PVP are mixed in water, they form an aggregated precipitate, which neither swells nor adheres to tissues. The formation of the hydrophobic complex was caused by hydrophobic interactions between the main chains of both polymers aligned the same as a zipper. To hinder the zipper-like alignment of the polymer main chains, hyaluronic acid (HA), a macromolecular viscous polysaccharide, was added to the PVP solution prior to complex formation. When the initial concentration of PAA was lower than 0.05%, HA effectively prevented the aggregation of PAA/PVP complexes and resulted in a slightly clouded suspension. Freeze-drying of the mixture yielded a soft white sponge, which could immediately swell in water to form a highly bioadhesive hydrogel. The PAA/PVP complex prepared with HA exhibited high hemostatic efficiency in clinical studies, even in patients on antithrombotic drugs.
format Online
Article
Text
id pubmed-9394286
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93942862022-08-23 Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis Ito, Tomoko Yamaguchi, Shingo Soga, Daisuke Yoshimoto, Takayuki Koyama, Yoshiyuki Gels Article Poly(acrylic acid) (PAA) is a water-soluble synthetic polymer that exhibits bioadhesive properties and has been applied in various novel medical devices, such as drug-delivery carriers and hemostatic agents. PAA forms a water-insoluble complex when mixed with polyvinylpyrrolidone (PVP). If PAA and PVP are mixed in water, they form an aggregated precipitate, which neither swells nor adheres to tissues. The formation of the hydrophobic complex was caused by hydrophobic interactions between the main chains of both polymers aligned the same as a zipper. To hinder the zipper-like alignment of the polymer main chains, hyaluronic acid (HA), a macromolecular viscous polysaccharide, was added to the PVP solution prior to complex formation. When the initial concentration of PAA was lower than 0.05%, HA effectively prevented the aggregation of PAA/PVP complexes and resulted in a slightly clouded suspension. Freeze-drying of the mixture yielded a soft white sponge, which could immediately swell in water to form a highly bioadhesive hydrogel. The PAA/PVP complex prepared with HA exhibited high hemostatic efficiency in clinical studies, even in patients on antithrombotic drugs. MDPI 2022-07-23 /pmc/articles/PMC9394286/ /pubmed/35892721 http://dx.doi.org/10.3390/gels8080462 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ito, Tomoko
Yamaguchi, Shingo
Soga, Daisuke
Yoshimoto, Takayuki
Koyama, Yoshiyuki
Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title_full Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title_fullStr Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title_full_unstemmed Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title_short Preparation of a Bioadhesive Poly(Acrylic Acid)/Polyvinylpyrrolidone Complex Gel and Its Clinical Effect on Dental Hemostasis
title_sort preparation of a bioadhesive poly(acrylic acid)/polyvinylpyrrolidone complex gel and its clinical effect on dental hemostasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394286/
https://www.ncbi.nlm.nih.gov/pubmed/35892721
http://dx.doi.org/10.3390/gels8080462
work_keys_str_mv AT itotomoko preparationofabioadhesivepolyacrylicacidpolyvinylpyrrolidonecomplexgelanditsclinicaleffectondentalhemostasis
AT yamaguchishingo preparationofabioadhesivepolyacrylicacidpolyvinylpyrrolidonecomplexgelanditsclinicaleffectondentalhemostasis
AT sogadaisuke preparationofabioadhesivepolyacrylicacidpolyvinylpyrrolidonecomplexgelanditsclinicaleffectondentalhemostasis
AT yoshimototakayuki preparationofabioadhesivepolyacrylicacidpolyvinylpyrrolidonecomplexgelanditsclinicaleffectondentalhemostasis
AT koyamayoshiyuki preparationofabioadhesivepolyacrylicacidpolyvinylpyrrolidonecomplexgelanditsclinicaleffectondentalhemostasis