Cargando…

The Impact of RNA Interference in Tick Research

Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al....

Descripción completa

Detalles Bibliográficos
Autores principales: de la Fuente, José, Kocan, Katherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394339/
https://www.ncbi.nlm.nih.gov/pubmed/35894050
http://dx.doi.org/10.3390/pathogens11080827
_version_ 1784771468536578048
author de la Fuente, José
Kocan, Katherine M.
author_facet de la Fuente, José
Kocan, Katherine M.
author_sort de la Fuente, José
collection PubMed
description Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission.
format Online
Article
Text
id pubmed-9394339
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93943392022-08-23 The Impact of RNA Interference in Tick Research de la Fuente, José Kocan, Katherine M. Pathogens Commentary Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission. MDPI 2022-07-23 /pmc/articles/PMC9394339/ /pubmed/35894050 http://dx.doi.org/10.3390/pathogens11080827 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
de la Fuente, José
Kocan, Katherine M.
The Impact of RNA Interference in Tick Research
title The Impact of RNA Interference in Tick Research
title_full The Impact of RNA Interference in Tick Research
title_fullStr The Impact of RNA Interference in Tick Research
title_full_unstemmed The Impact of RNA Interference in Tick Research
title_short The Impact of RNA Interference in Tick Research
title_sort impact of rna interference in tick research
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394339/
https://www.ncbi.nlm.nih.gov/pubmed/35894050
http://dx.doi.org/10.3390/pathogens11080827
work_keys_str_mv AT delafuentejose theimpactofrnainterferenceintickresearch
AT kocankatherinem theimpactofrnainterferenceintickresearch
AT delafuentejose impactofrnainterferenceintickresearch
AT kocankatherinem impactofrnainterferenceintickresearch