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The Impact of RNA Interference in Tick Research
Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394339/ https://www.ncbi.nlm.nih.gov/pubmed/35894050 http://dx.doi.org/10.3390/pathogens11080827 |
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author | de la Fuente, José Kocan, Katherine M. |
author_facet | de la Fuente, José Kocan, Katherine M. |
author_sort | de la Fuente, José |
collection | PubMed |
description | Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission. |
format | Online Article Text |
id | pubmed-9394339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93943392022-08-23 The Impact of RNA Interference in Tick Research de la Fuente, José Kocan, Katherine M. Pathogens Commentary Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission. MDPI 2022-07-23 /pmc/articles/PMC9394339/ /pubmed/35894050 http://dx.doi.org/10.3390/pathogens11080827 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary de la Fuente, José Kocan, Katherine M. The Impact of RNA Interference in Tick Research |
title | The Impact of RNA Interference in Tick Research |
title_full | The Impact of RNA Interference in Tick Research |
title_fullStr | The Impact of RNA Interference in Tick Research |
title_full_unstemmed | The Impact of RNA Interference in Tick Research |
title_short | The Impact of RNA Interference in Tick Research |
title_sort | impact of rna interference in tick research |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394339/ https://www.ncbi.nlm.nih.gov/pubmed/35894050 http://dx.doi.org/10.3390/pathogens11080827 |
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