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MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome

Background: Turner Syndrome (TS) is a relatively rare X-chromosomal disease with increased cardiovascular morbidity and mortality. This study aimed to identify whether the circulating miR-126-3p/5p are involved in the pathophysiology of vascular dysfunction in TS. Methods: Using the RT-qPCR, the abu...

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Autores principales: Abu-Halima, Masood, Oberhoffer, Felix Sebastian, Wagner, Viktoria, Abd El Rahman, Mohamed, Jung, Anna-Maria, Zemlin, Michael, Rohrer, Tilman R., Meese, Eckart, Abdul-Khaliq, Hashim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394385/
https://www.ncbi.nlm.nih.gov/pubmed/35892612
http://dx.doi.org/10.3390/children9081109
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author Abu-Halima, Masood
Oberhoffer, Felix Sebastian
Wagner, Viktoria
Abd El Rahman, Mohamed
Jung, Anna-Maria
Zemlin, Michael
Rohrer, Tilman R.
Meese, Eckart
Abdul-Khaliq, Hashim
author_facet Abu-Halima, Masood
Oberhoffer, Felix Sebastian
Wagner, Viktoria
Abd El Rahman, Mohamed
Jung, Anna-Maria
Zemlin, Michael
Rohrer, Tilman R.
Meese, Eckart
Abdul-Khaliq, Hashim
author_sort Abu-Halima, Masood
collection PubMed
description Background: Turner Syndrome (TS) is a relatively rare X-chromosomal disease with increased cardiovascular morbidity and mortality. This study aimed to identify whether the circulating miR-126-3p/5p are involved in the pathophysiology of vascular dysfunction in TS. Methods: Using the RT-qPCR, the abundance levels of miR-126-3p and miR-126-5p were determined in 33 TS patients and 33 age-matched healthy volunteers (HVs). Vascular screening, including the assessment of blood pressure, pulse wave velocity, augmentation index, aortic deformation, arterial distensibility, and arterial elastance, was conducted in TS patients and HVs. Results: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs (p < 0.0001). Within the TS cohort, miR-126-3p/5p correlated significantly with aortic deformation (r = 0.47, p = 0.01; r = 0.48, p < 0.01) and arterial distensibility (r = 0.55, p < 0.01; r = 0.48, p < 0.01). In addition, a significant negative correlation was demonstrated between miR-126-3p and arterial elastance (r = −0.48, p = 0.01). The receiver operating characteristic analysis showed that miR-126-3p and miR-126-5p separated the tested groups with high sensitivity and specificity. Conclusions: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs. Within the TS cohort, a lower abundance level of miR-126-3p and miR-126-5p was linked with a significantly higher aortic stiffness.
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spelling pubmed-93943852022-08-23 MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome Abu-Halima, Masood Oberhoffer, Felix Sebastian Wagner, Viktoria Abd El Rahman, Mohamed Jung, Anna-Maria Zemlin, Michael Rohrer, Tilman R. Meese, Eckart Abdul-Khaliq, Hashim Children (Basel) Article Background: Turner Syndrome (TS) is a relatively rare X-chromosomal disease with increased cardiovascular morbidity and mortality. This study aimed to identify whether the circulating miR-126-3p/5p are involved in the pathophysiology of vascular dysfunction in TS. Methods: Using the RT-qPCR, the abundance levels of miR-126-3p and miR-126-5p were determined in 33 TS patients and 33 age-matched healthy volunteers (HVs). Vascular screening, including the assessment of blood pressure, pulse wave velocity, augmentation index, aortic deformation, arterial distensibility, and arterial elastance, was conducted in TS patients and HVs. Results: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs (p < 0.0001). Within the TS cohort, miR-126-3p/5p correlated significantly with aortic deformation (r = 0.47, p = 0.01; r = 0.48, p < 0.01) and arterial distensibility (r = 0.55, p < 0.01; r = 0.48, p < 0.01). In addition, a significant negative correlation was demonstrated between miR-126-3p and arterial elastance (r = −0.48, p = 0.01). The receiver operating characteristic analysis showed that miR-126-3p and miR-126-5p separated the tested groups with high sensitivity and specificity. Conclusions: The abundance levels of miR-126-3p and miR-126-5p were significantly higher in TS patients compared to HVs. Within the TS cohort, a lower abundance level of miR-126-3p and miR-126-5p was linked with a significantly higher aortic stiffness. MDPI 2022-07-23 /pmc/articles/PMC9394385/ /pubmed/35892612 http://dx.doi.org/10.3390/children9081109 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abu-Halima, Masood
Oberhoffer, Felix Sebastian
Wagner, Viktoria
Abd El Rahman, Mohamed
Jung, Anna-Maria
Zemlin, Michael
Rohrer, Tilman R.
Meese, Eckart
Abdul-Khaliq, Hashim
MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title_full MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title_fullStr MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title_full_unstemmed MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title_short MicroRNA-126-3p/5p and Aortic Stiffness in Patients with Turner Syndrome
title_sort microrna-126-3p/5p and aortic stiffness in patients with turner syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394385/
https://www.ncbi.nlm.nih.gov/pubmed/35892612
http://dx.doi.org/10.3390/children9081109
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